{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:22:40Z","timestamp":1790511760181,"version":"4.1.0"},"reference-count":35,"publisher":"National Academy of Sciences","issue":"47","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,11,24]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The noncanonical NF-\u03baB signaling pathway via the serine kinase NIK (NF-\u03baB\u2013inducing kinase) is essential for normal immune system development and has been implicated in tumor cell survival and growth. Because NIK is under investigation as a therapeutic target, it is important to understand NIK\u2019s role in the context of a fully developed immune system, particularly in regard to mounting adaptive T-cell responses. We have generated and characterized transgenic mice with conditionally deleted NIK in CD11c\n                    <jats:sup>+<\/jats:sup>\n                    dendritic cells and observe impaired antigen cross-priming of a naive CD8 T-cell response. This defect results from defective antigen cross-presentation by CD8\n                    <jats:sup>+<\/jats:sup>\n                    dendritic cells and also is associated with their reduced ability to secrete IL-12p40, a cytokine known to promote cross-priming in vivo.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1520627112","type":"journal-article","created":{"date-parts":[[2015,11,11]],"date-time":"2015-11-11T21:58:54Z","timestamp":1447279134000},"page":"14664-14669","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":51,"title":["Dendritic cells require NIK for CD40-dependent cross-priming of CD8\n                    <sup>+<\/sup>\n                    T cells"],"prefix":"10.1073","volume":"112","author":[{"given":"Anand K.","family":"Katakam","sequence":"first","affiliation":[{"name":"Department of Pathology, Genentech Inc., South San Francisco, CA 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