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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,12,29]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    To determine whether genetic variation within the MHC locus influences the risk of developing systemic juvenile idiopathic arthritis (sJIA), we examined a dense set of MHC region single nucleotide polymorphisms, classic HLA alleles, and the individual amino acids of HLA molecules in nine independent sJIA case-control populations. Association testing revealed that genetic variants within the MHC class II gene cluster significantly influenced sJIA risk in every study population. The strongest risk factor for sJIA was\n                    <jats:italic>HLA-DRB1*11<\/jats:italic>\n                    , which conferred at least a two-fold increase in disease risk in each population studied. These data implicate the interaction of antigen presenting cells with T cells in the pathogenesis of sJIA.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1520779112","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T22:19:00Z","timestamp":1448317140000},"page":"15970-15975","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":160,"title":["<i>HLA-DRB1*11<\/i>\n                    and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis"],"prefix":"10.1073","volume":"112","author":[{"given":"Michael J.","family":"Ombrello","sequence":"first","affiliation":[{"name":"Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine F.","family":"Remmers","sequence":"additional","affiliation":[{"name":"Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Tachmazidou","sequence":"additional","affiliation":[{"name":"Human Genetics, The Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei","family":"Grom","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229;"},{"name":"Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Foell","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology and Immunology, University Hospital M\u00fcnster, D-48149 M\u00fcnster, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes-Peter","family":"Haas","sequence":"additional","affiliation":[{"name":"German Center for Pediatric and Adolescent Rheumatology, 82467 Garmisch-Partenkirchen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Martini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Genova, 16145 Genoa, Italy;"},{"name":"Pediatrics II Unit, G. 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