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Infectious diseases killed half of all children before the age of 15 y, but this enormous burden was caused by the dazzling diversity of pathogens rather than by the potency of individual pathogens. The key problem concerning pediatric infectious diseases thus was identified: their pathogenesis. A human genetic theory of infectious diseases has emerged gradually from clinical and epidemiological studies, building on many elegant studies in plants and animals.<\/jats:p>","DOI":"10.1073\/pnas.1521644112","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T23:15:18Z","timestamp":1448925318000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":179,"title":["Human genetic basis of interindividual variability in the course of infection"],"prefix":"10.1073","volume":"112","author":[{"given":"Jean-Laurent","family":"Casanova","sequence":"first","affiliation":[{"name":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065;"},{"name":"Howard Hughes Medical Institute, New York, NY 10065;"},{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U1163, Necker Hospital for Sick Children, 75015 Paris, France;"},{"name":"Imagine Institute, Paris Descartes University, 75015 Paris, France;"},{"name":"Pediatric Hematology and Immunology Unit, Assistance Publique\u2013H\u00f4pitaux de Paris, Necker Hospital for Sick Children, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,11,30]]},"reference":[{"key":"e_1_3_3_1_2","first-page":"181","article-title":"Les infections inapparentes","author":"Nicolle C","year":"1933","unstructured":"C Nicolle, Les infections inapparentes. 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