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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,12,29]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The\n                    <jats:italic>cobra<\/jats:italic>\n                    mutants of\n                    <jats:italic>Arabidopsis<\/jats:italic>\n                    , such as\n                    <jats:italic>cob-6<\/jats:italic>\n                    , have impaired growth associated with a defect in cellulose synthesis. Mutations in\n                    <jats:italic>MEDIATOR16<\/jats:italic>\n                    (\n                    <jats:italic>MED16<\/jats:italic>\n                    ) reduce the number of misregulated genes in\n                    <jats:italic>cob-6<\/jats:italic>\n                    mutants and suppress the phenotypes. This observation implicates\n                    <jats:italic>MED16<\/jats:italic>\n                    in transcriptional responses to cell wall defects. Ectopic expression of two pectin methylesterase inhibitors (PMEIs) identified in a suppressor screen partially suppressed the growth defect in the\n                    <jats:italic>cob-6<\/jats:italic>\n                    mutant. The results confirm that the PMEIs have significant in vivo activity, and provide evidence that pectin esterification can modulate cell wall properties.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1521675112","type":"journal-article","created":{"date-parts":[[2015,12,11]],"date-time":"2015-12-11T22:49:00Z","timestamp":1449874140000},"page":"16048-16053","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":38,"title":["Identification of MEDIATOR16 as the\n                    <i>Arabidopsis<\/i>\n                    COBRA suppressor MONGOOSE1"],"prefix":"10.1073","volume":"112","author":[{"given":"Nadav","family":"Sorek","sequence":"first","affiliation":[{"name":"Energy Biosciences Institute, University of California, Berkeley, CA 94720;"},{"name":"Plant and Microbial Biology Department, University of California, Berkeley, CA 94720;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Szemenyei","sequence":"additional","affiliation":[{"name":"Energy Biosciences Institute, University of California, Berkeley, CA 94720;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagit","family":"Sorek","sequence":"additional","affiliation":[{"name":"Energy Biosciences Institute, University of California, Berkeley, CA 94720;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Landers","sequence":"additional","affiliation":[{"name":"Energy Biosciences Institute, University of California, Berkeley, CA 94720;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Knight","sequence":"additional","affiliation":[{"name":"School of Biological and Biomedical Sciences, Durham University, Durham DH1 3LE, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Bauer","sequence":"additional","affiliation":[{"name":"Energy Biosciences Institute, University of California, Berkeley, CA 94720;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Wemmer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of California, Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris R.","family":"Somerville","sequence":"additional","affiliation":[{"name":"Energy Biosciences Institute, University of California, Berkeley, CA 94720;"},{"name":"Plant and Microbial Biology Department, University of California, Berkeley, CA 94720;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,12,11]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1126\/science.1102765","article-title":"Toward a systems approach to understanding plant cell walls","volume":"306","author":"Somerville C","year":"2004","unstructured":"C Somerville, , Toward a systems approach to understanding plant cell walls. 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