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Interestingly, Colly exhibits biased agonistic activity, suggesting that it could be used as a backbone for the generation of novel therapeutics targeting \u03baOR with reduced side effects.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1521825113","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T00:09:33Z","timestamp":1462838973000},"page":"6041-6046","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":36,"title":["Collybolide is a novel biased agonist of \u03ba-opioid receptors with potent antipruritic activity"],"prefix":"10.1073","volume":"113","author":[{"given":"Achla","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Pharmacology &amp; Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivone","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin N.","family":"Bobeck","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda K.","family":"Fakira","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas P.","family":"Massaro","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indrajeet","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Cav\u00e9","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi E.","family":"Hamm","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Parello","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232;"},{"name":"Department of Chemistry, Vanderbilt University, Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2179-2874","authenticated-orcid":false,"given":"Lakshmi A.","family":"Devi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,5,9]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00008-4"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161281942140105163727"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.73.011303.073940"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0022-3565(25)39097-X","article-title":"Kappa opioids in rhesus monkeys. 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