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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,1,19]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>The four dengue virus serotypes (DENV1\u20134) are the most prevalent arboviruses worldwide and cause outcomes ranging from inapparent infection to severe disease. Neutralizing antibodies are believed to be critical for protection and therefore for dengue vaccines, but the titers required to prevent symptomatic DENV infection have not been well established. Here, we show that higher preinfection neutralizing antibody titers correlate with lower probability of symptomatic infection in children in a longitudinal cohort study in Nicaragua. Further, we find evidence that levels of cross-reactive neutralizing antibodies are maintained over time, possibly due to reexposure. These findings provide insight into the determinants of DENV infection outcome and long-term immunity in an endemic setting and are relevant for dengue vaccine development.<\/jats:p>","DOI":"10.1073\/pnas.1522136113","type":"journal-article","created":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T21:30:13Z","timestamp":1451943013000},"page":"728-733","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":199,"title":["Neutralizing antibody titers against dengue virus correlate with protection from symptomatic infection in a longitudinal cohort"],"prefix":"10.1073","volume":"113","author":[{"given":"Leah C.","family":"Katzelnick","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, CA 94720-3370;"},{"name":"Centre for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magelda","family":"Montoya","sequence":"additional","affiliation":[{"name":"Centre for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Gresh","sequence":"additional","affiliation":[{"name":"Sustainable Sciences Institute, Managua, Nicaragua;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Balmaseda","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional de Virolog\u00eda, Centro Nacional de Diagn\u00f3stico y Referencia, Ministry of Health, Managua, Nicaragua"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Harris","sequence":"additional","affiliation":[{"name":"Centre for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,1,4]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12060"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60572-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-1348(03)00004-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.131.3407.1102"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1302.060539"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1952.1.30"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit436"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2013.0414"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002357"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113932"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/140.4.527"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit273"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61428-7"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1988.38.411"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/519170"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000171"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/382280"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003230"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu481"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1086\/648592"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002462"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027252"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2003.68.191"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000670"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001394"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00280"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2006.74.449"},{"key":"e_1_3_3_28_2","first-page":"231","volume-title":"Dengue and Dengue Hemorrhagic Fever","author":"OhAinle M","year":"2014","unstructured":"M OhAinle, E Harris, Dengue pathogenesis: Viral factors. 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