{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:07:22Z","timestamp":1790903242864,"version":"4.1.0"},"reference-count":39,"publisher":"National Academy of Sciences","issue":"15","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2002,7,23]]},"abstract":"<jats:p>\n                    Malaria is a complex infectious disease in which the host\/parasite interaction is strongly influenced by host genetic factors. The consequences of plasmodial infections range from asymptomatic to severe complications like the neurological syndrome cerebral malaria induced by\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    in humans and\n                    <jats:italic>Plasmodium berghei<\/jats:italic>\n                    ANKA in rodents. Mice infected with\n                    <jats:italic>P. berghei<\/jats:italic>\n                    ANKA show marked differences in disease manifestation and either die from experimental cerebral malaria (ECM) or from hemolytic anemia caused by hyperparasitemia (HP). A majority of laboratory mouse strains so far investigated are susceptible to ECM; however, a number of wild-derived inbred strains show resistance. To evaluate the genetic basis of this difference, we crossed a uniquely ECM-resistant, wild-derived inbred strain (WLA) with an ECM susceptible laboratory strain (C57BL\/6J). All of the (WLA \u00d7 C57BL\/6J) F\n                    <jats:sub>1<\/jats:sub>\n                    and 97% of the F\n                    <jats:sub>2<\/jats:sub>\n                    progeny displayed ECM resistance similar to the WLA strain. To screen for loci contributing to ECM resistance, we analyzed a cohort of mice backcrossed to the C57BL\/6J parental strain. A genome wide screening of this cohort provided significant linkage of ECM resistance to marker loci in two genetic regions on chromosome 1 (\u03c7\n                    <jats:sup>2<\/jats:sup>\n                    = 18.98,\n                    <jats:italic>P<\/jats:italic>\n                    = 1.3 \u00d7 10\n                    <jats:sup>\u22125<\/jats:sup>\n                    ) and on chromosome 11 (\u03c7\n                    <jats:sup>2<\/jats:sup>\n                    = 16.51,\n                    <jats:italic>P<\/jats:italic>\n                    = 4.8 \u00d7 10\n                    <jats:sup>\u22125<\/jats:sup>\n                    ), being designated\n                    <jats:italic>Berr1<\/jats:italic>\n                    and\n                    <jats:italic>Berr2<\/jats:italic>\n                    , respectively. These data provide the first evidence of loci associated with resistance to murine cerebral malaria, which may have important implications for the search for genetic factors controlling cerebral malaria in humans.\n                  <\/jats:p>","DOI":"10.1073\/pnas.152215199","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T18:26:28Z","timestamp":1027880788000},"page":"9919-9923","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":51,"title":["Identification of two cerebral malaria resistance loci using an inbred wild-derived mouse strain"],"prefix":"10.1073","volume":"99","author":[{"given":"S\u00e9bastien","family":"Bagot","sequence":"first","affiliation":[{"name":"Unit\u00e9 Immunophysiopathologie Infectieuse, Institut Pasteur, Centre National de la Recherche Scientifique, Unit\u00e9 de Recherche Associ\u00e9e 1961, and Universit\u00e9 Pierre et Marie Curie, 75005 Paris, France; Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal; Ume\u00e5 Center for Molecular Medicine, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden; and Institut National de la Sant\u00e9 de la Recherche M\u00e9dicale U511, CHU Piti\u00e9-Salp\u00eatri\u00e8re, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Campino","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Immunophysiopathologie Infectieuse, Institut Pasteur, Centre National de la Recherche Scientifique, Unit\u00e9 de Recherche Associ\u00e9e 1961, and Universit\u00e9 Pierre et Marie Curie, 75005 Paris, France; Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal; Ume\u00e5 Center for Molecular Medicine, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden; and Institut National de la Sant\u00e9 de la Recherche M\u00e9dicale U511, CHU Piti\u00e9-Salp\u00eatri\u00e8re, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Penha-Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Immunophysiopathologie Infectieuse, Institut Pasteur, Centre National de la Recherche Scientifique, Unit\u00e9 de Recherche Associ\u00e9e 1961, and Universit\u00e9 Pierre et Marie Curie, 75005 Paris, France; Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal; Ume\u00e5 Center for Molecular Medicine, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden; and Institut National de la Sant\u00e9 de la Recherche M\u00e9dicale U511, CHU Piti\u00e9-Salp\u00eatri\u00e8re, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylviane","family":"Pied","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Immunophysiopathologie Infectieuse, Institut Pasteur, Centre National de la Recherche Scientifique, Unit\u00e9 de Recherche Associ\u00e9e 1961, and Universit\u00e9 Pierre et Marie Curie, 75005 Paris, France; Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal; Ume\u00e5 Center for Molecular Medicine, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden; and Institut National de la Sant\u00e9 de la Recherche M\u00e9dicale U511, CHU Piti\u00e9-Salp\u00eatri\u00e8re, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Andr\u00e9","family":"Cazenave","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Immunophysiopathologie Infectieuse, Institut Pasteur, Centre National de la Recherche Scientifique, Unit\u00e9 de Recherche Associ\u00e9e 1961, and Universit\u00e9 Pierre et Marie Curie, 75005 Paris, France; Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal; Ume\u00e5 Center for Molecular Medicine, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden; and Institut National de la Sant\u00e9 de la Recherche M\u00e9dicale U511, CHU Piti\u00e9-Salp\u00eatri\u00e8re, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Immunophysiopathologie Infectieuse, Institut Pasteur, Centre National de la Recherche Scientifique, Unit\u00e9 de Recherche Associ\u00e9e 1961, and Universit\u00e9 Pierre et Marie Curie, 75005 Paris, France; Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal; Ume\u00e5 Center for Molecular Medicine, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden; and Institut National de la Sant\u00e9 de la Recherche M\u00e9dicale U511, CHU Piti\u00e9-Salp\u00eatri\u00e8re, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2002,7,11]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1997.tb01075.x"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1996.11813068"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(05)80020-9"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1997.11813173"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1381.1999.99234.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5354.1173"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2000.00342.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200007668X"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(00)00087-3"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/352595a0"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/314533"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/371508a0"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/9649"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.2001.00995.x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(95)80018-2"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1297-380"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1297-382"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002510050603"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191288998"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-001-0390-z"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.4.2049-2056.2002"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.2307\/3274665"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/95.1.114"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.2.512-516.2002"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2002.6570"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.9.4093-4099.1998"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-679X(08)61081-X"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1995.1167"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/158.1.357"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1195-241"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/71641"},{"key":"e_1_3_3_32_2","first-page":"1577","volume-title":"Genetic Variants and Strains of the Laboratory Mouse","author":"Bonhomme F","year":"1996","unstructured":"F Bonhomme, J-L Gu\u00e9net Genetic Variants and Strains of the Laboratory Mouse, eds M F Lyon, S Rastan, S Brown (Oxford Univ. 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