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Thus, our studies implicate BRD4 as a global genomic regulator of the fibrotic gene regulatory network and suggest bromodomains as potential therapeutic targets to treat fibrotic complications in patients.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1522163112","type":"journal-article","created":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T20:57:55Z","timestamp":1449608275000},"page":"15713-15718","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":200,"title":["BRD4 is a novel therapeutic target for liver fibrosis"],"prefix":"10.1073","volume":"112","author":[{"given":"Ning","family":"Ding","sequence":"first","affiliation":[{"name":"Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasun","family":"Hah","sequence":"additional","affiliation":[{"name":"Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth T.","family":"Yu","sequence":"additional","affiliation":[{"name":"Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara H.","family":"Sherman","sequence":"additional","affiliation":[{"name":"Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Benner","sequence":"additional","affiliation":[{"name":"Razzavi Newman Integrated Genomics and Bioinformatics Core, Salk Institute for Biological Studies, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Leblanc","sequence":"additional","affiliation":[{"name":"Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxiao","family":"He","sequence":"additional","affiliation":[{"name":"Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Liddle","sequence":"additional","affiliation":[{"name":"Storr Liver Unit, Westmead Millennium Institute and University of Sydney, Westmead Hospital, Westmead, New South Wales 2145, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Downes","sequence":"additional","affiliation":[{"name":"Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald M.","family":"Evans","sequence":"additional","affiliation":[{"name":"Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037;"},{"name":"Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,12,7]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: Therapeutic translation for fibrotic disease","volume":"18","author":"Wynn TA","year":"2012","unstructured":"TA Wynn, TR Ramalingam, Mechanisms of fibrosis: Therapeutic translation for fibrotic disease. 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