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Comparing the genomes of parasites restricted to growth in culture with cynomolgus RBCs and those adapted to growth in human RBCs identified a gene specifically required for invasion of human RBCs, a process that is critical for parasite replication. This gene encodes normocyte-binding protein Xa, a protein previously shown to bind human RBCs and implicated in invasion. Disruption of this gene blocks invasion of human but not cynomolgus RBCs, thus confirming a key mediator of human infection and a potential target for inclusion in vaccines to prevent human infection.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1522469113","type":"journal-article","created":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T09:21:07Z","timestamp":1465982467000},"page":"7231-7236","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":80,"title":["Normocyte-binding protein required for human erythrocyte invasion by the zoonotic malaria parasite\n                    <i>Plasmodium knowlesi<\/i>"],"prefix":"10.1073","volume":"113","author":[{"given":"Robert W.","family":"Moon","sequence":"first","affiliation":[{"name":"Mill Hill Laboratory, The Francis Crick Institute, London NW7 1AA, United Kingdom;"},{"name":"Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of 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