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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,5,24]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The inner ear is a vertebrate organ of delicate and complex architecture that translates sound into electrical signals deciphered by the brain. This study utilizes a genetic approach to associate a mutation of\n                    <jats:italic>ROR1<\/jats:italic>\n                    (receptor tyrosine kinase-like orphan receptor 1) with inner ear anomalies and deafness in humans. Characterization of\n                    <jats:italic>Ror1<\/jats:italic>\n                    mutant mice reveals fasciculation deficiencies of spiral ganglion axons and disruption of sensory hair cell synapses and peripheral innervations. The molecular basis of this phenotype involves alterations of the NF-\u03baB pathway. Thus, we present\n                    <jats:italic>ROR1<\/jats:italic>\n                    as a previously unrecognized gene that is essential for the development of the inner ear and hearing in humans and mice.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1522512113","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T00:09:33Z","timestamp":1462838973000},"page":"5993-5998","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":56,"title":["ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice"],"prefix":"10.1073","volume":"113","author":[{"given":"Oscar","family":"Diaz-Horta","sequence":"first","affiliation":[{"name":"John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemer","family":"Abad","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levent","family":"Sennaroglu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Hacettepe University School of Medicine, Ankara, 06100, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Joseph","family":"Foster","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"DeSmidt","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Miami, Miami, FL 33146;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guney","family":"Bademci","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suna","family":"Tokgoz-Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Hacettepe University School of Medicine, Ankara, 06100, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7583-0349","authenticated-orcid":false,"given":"Duygu","family":"Duman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Genetics, Ankara University School of Medicine, Ankara, 06100, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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