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This is achieved by perturbing the activity of the phosphatidylinositol 5-kinase PIKfyve, leading to an enrichment of PI(3)P on CCV membranes, which is required for the autophagy machinery to mediate CCV homotypic fusion. The importance of this process is highlighted by a homotypic fusion defect between CCVs in cells infected with CvpB\n                    <jats:italic>Coxiella<\/jats:italic>\n                    mutants, which translates into an attenuated virulence in the insect model\n                    <jats:italic>Galleria mellonella<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1073\/pnas.1522811113","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:25:24Z","timestamp":1464222324000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":127,"title":["<i>Coxiella burnetii<\/i>\n                    effector CvpB modulates phosphoinositide metabolism for optimal vacuole development"],"prefix":"10.1073","volume":"113","author":[{"given":"Eric","family":"Martinez","sequence":"first","affiliation":[{"name":"CNRS, Formation de Recherche en \u00c9volution 3689, Centre 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