{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:50:37Z","timestamp":1790614237976,"version":"4.1.0"},"reference-count":35,"publisher":"National Academy of Sciences","issue":"1","license":[{"start":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T00:00:00Z","timestamp":1466553600000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/www.pnas.org\/preview_site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["AG40132"],"award-info":[{"award-number":["AG40132"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK80459"],"award-info":[{"award-number":["DK80459"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR06592"],"award-info":[{"award-number":["AR06592"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR06066"],"award-info":[{"award-number":["AR06066"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["AG23176"],"award-info":[{"award-number":["AG23176"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,1,5]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>We show that oxytocin and vasopressin, which are released from the posterior pituitary gland to regulate lactation and water balance, respectively, are potent regulators of skeletal integrity. Using genetically modified mice and chemical inhibitors, we provide evidence that the two hormones interact with each other\u2019s receptors to control precisely the formation of new bone.<\/jats:p>","DOI":"10.1073\/pnas.1523762113","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T20:07:30Z","timestamp":1450901250000},"page":"164-169","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":77,"title":["Functions of vasopressin and oxytocin in bone mass regulation"],"prefix":"10.1073","volume":"113","author":[{"given":"Li","family":"Sun","sequence":"first","affiliation":[{"name":"The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Tamma","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Neurosciences and Sensory Organs, University of Bari, 70124 Bari, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Yuen","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziana","family":"Colaianni","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Neurosciences and Sensory Organs, University of Bari, 70124 Bari, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoting","family":"Ji","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Cuscito","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Neurosciences and Sensory Organs, University of Bari, 70124 Bari, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Bailey","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samarth","family":"Dhawan","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Lu","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosima D.","family":"Calvano","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Bari Aldo Moro, Bari 70124, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Ling","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo G.","family":"Zambonin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Bari Aldo Moro, Bari 70124, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Di Benedetto","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Foggia, Foggia 71122, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Stachnik","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Grano","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Neurosciences and Sensory Organs, University of Bari, 70124 Bari, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Colucci","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Neurosciences and Sensory Organs, University of Bari, 70124 Bari, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry F.","family":"Davies","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"New","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberta","family":"Zallone","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Neurosciences and Sensory Organs, University of Bari, 70124 Bari, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mone","family":"Zaidi","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,12,22]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12120"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901890106"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1318257110"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00771-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05231.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.051"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1593"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912176107"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.07.148"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.365049"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.21.11699"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/357333a0"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)47129-3"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.43.25771"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb07211.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST0350717"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08112.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1419349111"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/15640"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1586\/erp.12.30"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2031"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.09.026"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06120809"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090827"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcn061"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-009-9585-2"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.155002"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.380"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0890411"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00477.2004"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.4172\/2329-9509.1000121"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfn004"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs002"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022800716196"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0892"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1523762113","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1523762113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T01:21:43Z","timestamp":1649812903000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1523762113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,22]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1,5]]}},"alternative-id":["10.1073\/pnas.1523762113"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1523762113","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,22]]},"assertion":[{"value":"2015-12-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}