{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:01:03Z","timestamp":1791259263663,"version":"4.1.0"},"reference-count":23,"publisher":"National Academy of Sciences","issue":"3","license":[{"start":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T00:00:00Z","timestamp":1467676800000},"content-version":"vor","delay-in-days":182,"URL":"http:\/\/www.pnas.org\/preview_site\/misc\/userlicense.xhtml"}],"funder":[{"name":"Leon Bromberg and Robert E. Shope, John S. Dunn Dist. 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The latter three strains constitute a clonal group, whereas NF1 is phylogenetically distinct. We tested these strains individually in a mouse intramuscular model of infection and observed NF1 to be less virulent than NF2. However, when NF1 and NF2 were mixed, NF1 exhibited more virulence and it decreased NF2 virulence. The cross-talk between NF1 and NF2 was due to the presence of ExoA toxin in NF2, ability of NF1 and NF2 to differentially modulate innate immune mechanism(s), and direct killing of NF2 by NF1.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1523817113","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T22:11:35Z","timestamp":1452031895000},"page":"722-727","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":124,"title":["Cross-talk among flesh-eating\n                    <i>Aeromonas hydrophila<\/i>\n                    strains in mixed infection leading to necrotizing fasciitis"],"prefix":"10.1073","volume":"113","author":[{"given":"Duraisamy","family":"Ponnusamy","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena V.","family":"Kozlova","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Sha","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana E.","family":"Erova","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha R.","family":"Azar","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric C.","family":"Fitts","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"Kirtley","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany L.","family":"Tiner","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jourdan A.","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Grim","sequence":"additional","affiliation":[{"name":"Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Food and Drug Administration, Laurel, MD 20708;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Isom","sequence":"additional","affiliation":[{"name":"CosmosID Inc., Rockville, MD 20850;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur A.","family":"Hasan","sequence":"additional","affiliation":[{"name":"CosmosID Inc., Rockville, MD 20850;"},{"name":"Center for Bioinformatics and Computational Biology, University of Maryland Institute for Advanced Computer Studies, University of Maryland, College Park, MD 20742;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita R.","family":"Colwell","sequence":"additional","affiliation":[{"name":"CosmosID Inc., Rockville, MD 20850;"},{"name":"Center for Bioinformatics and Computational Biology, University of Maryland Institute for Advanced Computer Studies, University of Maryland, College Park, MD 20742;"},{"name":"Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok K.","family":"Chopra","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,1,5]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/1749-7922-6-46"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2008.10.032"},{"key":"e_1_3_3_3_2","first-page":"5256","article-title":"Multi-limb necrotizing fasciitis in a patient with rectal cancer","volume":"12","author":"Liu SYW","year":"2006","unstructured":"SYW Liu, SSM Ng, JFY Lee, Multi-limb necrotizing fasciitis in a patient with rectal cancer. 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