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As proof of concept, administration of sgRNA against the\n                    <jats:italic>Myh6<\/jats:italic>\n                    gene induced\n                    <jats:italic>Myh6<\/jats:italic>\n                    editing, resulting in cardiomyopathy and heart failure in the cardiac-specific Cas9 mouse. This transgenic mouse model offers a valuable tool for cardiovascular research, as a straightforward strategy to edit genes of interest in the heart.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1523918113","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T22:23:57Z","timestamp":1451514237000},"page":"338-343","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":169,"title":["A mouse model for adult cardiac-specific gene deletion with CRISPR\/Cas9"],"prefix":"10.1073","volume":"113","author":[{"given":"Kelli J.","family":"Carroll","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and the Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Makarewich","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and the Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"McAnally","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and the Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas M.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and the Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Zentilin","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, I-34149 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and the Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Giacca","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, I-34149 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda","family":"Bassel-Duby","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and the Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric N.","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and the Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 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