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U.S.A."],"published-print":{"date-parts":[[2016,6,14]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Polysaccharide capsules are protective surface layers that enhance virulence of many pathogenic bacteria.\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    serovar Typhi is the causative agent of typhoid fever, and it produces the virulence capsular polysaccharide known as \u201cVi antigen.\u201d This glycan is part of some current vaccines. In some Gram-negative bacteria, capsular polysaccharides are attached to a conserved glycolipid that anchors the polysaccharide to the cell surface and is required for its transport across the cell envelope.\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>enterica<\/jats:italic>\n                    Typhi follows a different strategy; this work identifies a reducing terminal lipid structure unique to the Vi antigen that is required for attachment of the capsular surface layer. This lipid is structurally (and potentially biosynthetically) related to the conserved lipid A component of bacterial lipopolysaccharides.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1524665113","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:25:24Z","timestamp":1464222324000},"page":"6719-6724","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":55,"title":["Unique lipid anchor attaches Vi antigen capsule to the surface of\n                    <i>Salmonella enterica<\/i>\n                    serovar Typhi"],"prefix":"10.1073","volume":"113","author":[{"given":"Sean D.","family":"Liston","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada, N1G2W1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga G.","family":"Ovchinnikova","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada, N1G2W1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5267-7027","authenticated-orcid":false,"given":"Chris","family":"Whitfield","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada, N1G2W1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,5,25]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev.biochem.75.103004.142545","article-title":"Biosynthesis and assembly of capsular polysaccharides in Escherichia coli","volume":"75","author":"Whitfield C","year":"2006","unstructured":"C Whitfield, Biosynthesis and assembly of capsular polysaccharides in Escherichia coli. 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