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An endosomal regulatory interaction of a lipid G-protein coupled receptor (GPCR) and IFNAR1 balances effective and detrimental components of immune responses and provides a previously unidentified pathway that contributes to significant and unexpected efficacy in clinical trials in multiple sclerosis, ulcerative colitis, psoriasis, and likely other diseases with aberrant IFN-\u03b1 signatures.<\/jats:p>","DOI":"10.1073\/pnas.1525356113","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T15:22:15Z","timestamp":1454426535000},"page":"1351-1356","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":61,"title":["S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-\u03b1 autoamplification"],"prefix":"10.1073","volume":"113","author":[{"given":"John R.","family":"Teijaro","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037;"},{"name":"Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Studer","sequence":"additional","affiliation":[{"name":"Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Leaf","sequence":"additional","affiliation":[{"name":"Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Kiosses","sequence":"additional","affiliation":[{"name":"Core Microscopy Facility, The Scripps Research Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhan","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Matsuki","sequence":"additional","affiliation":[{"name":"Department of Molecular Immunology, Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Negishi","sequence":"additional","affiliation":[{"name":"Department of Molecular Immunology, Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadatsugu","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Molecular Immunology, Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B. 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