{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:44:31Z","timestamp":1790671471276,"version":"4.1.0"},"reference-count":41,"publisher":"National Academy of Sciences","issue":"28","license":[{"start":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T00:00:00Z","timestamp":1482537600000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/www.pnas.org\/preview_site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["24247037"],"award-info":[{"award-number":["24247037"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology, Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["12J04387"],"award-info":[{"award-number":["12J04387"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,7,12]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Claudin-1<\/jats:italic>\n                    (\n                    <jats:italic>CLDN1<\/jats:italic>\n                    ), which is thought to be a key gene for human skin disease, especially atopic dermatitis (AD), encodes the dominant claudin responsible for the paracellular barrier at tight junctions in the epidermis. Although decreased\n                    <jats:italic>CLDN1<\/jats:italic>\n                    expression levels are reported in AD patients, it has been difficult to study how CLDN1 contributes to AD development, mainly because\n                    <jats:italic>Cldn1<\/jats:italic>\n                    knock-out mice die within 1 d after birth from dehydration. In this report, we reproduced features of human AD in mice, by systematically regulating the\n                    <jats:italic>Cldn1<\/jats:italic>\n                    expression level. Our experimental approach contributes to the understanding of AD\u2019s etiology and suggests a therapeutic target for this disorder.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1525474113","type":"journal-article","created":{"date-parts":[[2016,6,26]],"date-time":"2016-06-26T02:05:09Z","timestamp":1466906709000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":129,"title":["Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis"],"prefix":"10.1073","volume":"113","author":[{"given":"Reitaro","family":"Tokumasu","sequence":"first","affiliation":[{"name":"Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Yamaga","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan;"},{"name":"Department of Dermatology, Course of integrated Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan;"},{"name":"Lewis\u2013Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Murota","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Course of integrated Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koya","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Tamura","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Bando","sequence":"additional","affiliation":[{"name":"Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology, 2-2-3 Minatojima Minami-machi, Chuou-ku, Kobe 650-0047, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhide","family":"Furuta","sequence":"additional","affiliation":[{"name":"Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology, 2-2-3 Minatojima Minami-machi, Chuou-ku, Kobe 650-0047, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Course of integrated Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Tsukita","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,6,24]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.01.028"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/35067088"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.09.019"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.68.040104.131404"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.07.022"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080973"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12724"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.018"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.06.021"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200110122"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.01.002"},{"key":"e_1_3_3_12_2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2340\/00015555924447","article-title":"Diagnostic features of atopic dermatitis","volume":"92","author":"Hanifin JM","year":"1980","unstructured":"JM Hanifin, G Rajka, Diagnostic features of atopic dermatitis. Acta Derm Venereol Suppl (Stockh) 92, 44\u201347 (1980).","journal-title":"Acta Derm Venereol Suppl (Stockh)"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2010.22.2.125"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12753"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2012.4.1.12"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70050-3"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/354250"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.13-RAI-0564"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.05.048"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/mend.14.7.0465"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200410083"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.O-06-458"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22621.x"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04508.x"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2769"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.01.068"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70246-4"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2014.11.007"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1767"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.10.040"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1493"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.199"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.507"},{"key":"e_1_3_3_34_2","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.4049\/jimmunol.159.5.2484","article-title":"Repeated elicitation of contact hypersensitivity induces a shift in cutaneous cytokine milieu from a T helper cell type 1 to a T helper cell type 2 profile","volume":"159","author":"Kitagaki H","year":"1997","unstructured":"H Kitagaki, , Repeated elicitation of contact hypersensitivity induces a shift in cutaneous cytokine milieu from a T helper cell type 1 to a T helper cell type 2 profile. J Immunol 159, 2484\u20132491 (1997).","journal-title":"J Immunol"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.02.001"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.03.150"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.07.044"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e10-12-1003"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000148"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.071191"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.06.009"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1525474113","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1525474113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T21:01:15Z","timestamp":1692392475000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1525474113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,24]]},"references-count":41,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2016,7,12]]}},"alternative-id":["10.1073\/pnas.1525474113"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1525474113","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,24]]},"assertion":[{"value":"2016-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}