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DSBs occur near TSSs of highly transcribed genes involved in general cellular processes but occur less often near neural-specific TSSs. These TSS-associated DSBs can translocate to other DSBs by both the normal and alternative DSB repair pathways. We report similar findings in B lymphocytes, suggesting that highly transcribed genes involved in general cellular processes are subject to TSS-associated DSBs in divergent cell types.<\/jats:p>","DOI":"10.1073\/pnas.1525564113","type":"journal-article","created":{"date-parts":[[2016,2,13]],"date-time":"2016-02-13T07:34:11Z","timestamp":1455348851000},"page":"2258-2263","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":101,"title":["Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem\/progenitor cells"],"prefix":"10.1073","volume":"113","author":[{"given":"Bjoern","family":"Schwer","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Boston, MA 02115;"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115;"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Chi","family":"Wei","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Boston, MA 02115;"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115;"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia N.","family":"Chang","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Boston, MA 02115;"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115;"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Kao","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Boston, MA 02115;"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115;"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Du","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Boston, MA 02115;"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115;"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin M.","family":"Meyers","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Boston, MA 02115;"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115;"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick W.","family":"Alt","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Boston, MA 02115;"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115;"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,2,12]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-genet-111212-133232","article-title":"Causes of genome instability","volume":"47","author":"Aguilera A","year":"2013","unstructured":"A Aguilera, T Garc\u00eda-Muse, Causes of genome instability. 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