{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:32:54Z","timestamp":1790976774373,"version":"4.1.0"},"reference-count":37,"publisher":"National Academy of Sciences","issue":"16","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2003,8,5]]},"abstract":"<jats:p>\n                    The proapoptotic activity of the \u201cBH3-only\u201d molecule BAD can be\n differentially regulated by survival factor signaling.\n                    <jats:italic>Bad<\/jats:italic>\n                    -deficient\n mice lacking both BAD long and BAD short proteins proved viable, and most cell\n types appeared to develop normally. BAD did not exclusively account for cell\n death after withdrawal of survival factors, but it was an intermediate for\n epidermal growth factor- or insulin-like growth factor I-countered apoptosis,\n consistent with a \u201csensitizing\u201d BH3-only molecule. Lymphocytes\n developed normally with no premalignant hyperplasia, but they displayed subtle\n abnormalities in proliferation and IgG production. Despite the minimal\n phenotype,\n                    <jats:italic>Bad<\/jats:italic>\n                    -deficient mice progressed, with aging, to diffuse\n large B cell lymphoma of germinal center origin. Exposure of\n                    <jats:italic>Bad<\/jats:italic>\n                    -null\n mice to sublethal \u03b3-irradiation resulted in an increased incidence of\n pre-T cell and pro-\/pre-B cell lymphoblastic leukemia\/lymphoma. Thus,\n proapoptotic BAD suppresses tumorigenesis in the lymphocyte lineage.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1533446100","type":"journal-article","created":{"date-parts":[[2003,8,5]],"date-time":"2003-08-05T13:14:48Z","timestamp":1060089288000},"page":"9324-9329","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":234,"title":["<i>Bad<\/i>\n                    -deficient mice develop diffuse large B cell lymphoma"],"prefix":"10.1073","volume":"100","author":[{"given":"Ann M.","family":"Ranger","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute and Departments\r of Pathology and Medicine, Harvard Medical School and Dana\u2013Farber Cancer\r Institute, Boston, MA 02115; Division of\r Neuroscience, Children's Hospital Boston and Department of Neurobiology,\r Harvard Medical School, Boston, MA 02115; School\r of Biological Sciences, University of Manchester, Manchester M13 9PT, United\r Kingdom; Department of Pathology, Brigham and\r Women's Hospital, Boston, MA 02115; and Section of\r Hematology\/Oncology, University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Zha","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and Departments\r of Pathology and Medicine, Harvard Medical School and Dana\u2013Farber Cancer\r Institute, Boston, MA 02115; Division of\r Neuroscience, Children's Hospital Boston and Department of Neurobiology,\r Harvard Medical School, Boston, MA 02115; School\r of Biological Sciences, University of Manchester, Manchester M13 9PT, United\r Kingdom; Department of Pathology, Brigham and\r Women's Hospital, Boston, MA 02115; and Section of\r Hematology\/Oncology, University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Harada","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and Departments\r of Pathology and Medicine, Harvard Medical School and Dana\u2013Farber Cancer\r Institute, Boston, MA 02115; Division of\r Neuroscience, Children's Hospital Boston and Department of Neurobiology,\r Harvard Medical School, Boston, MA 02115; School\r of Biological Sciences, University of Manchester, Manchester M13 9PT, United\r Kingdom; Department of Pathology, Brigham and\r Women's Hospital, Boston, MA 02115; and Section of\r Hematology\/Oncology, University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep Robert","family":"Datta","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and Departments\r of Pathology and Medicine, Harvard Medical School and Dana\u2013Farber Cancer\r Institute, Boston, MA 02115; Division of\r Neuroscience, Children's Hospital Boston and Department of Neurobiology,\r Harvard Medical School, Boston, MA 02115; School\r of Biological Sciences, University of Manchester, Manchester M13 9PT, United\r Kingdom; Department of Pathology, Brigham and\r Women's Hospital, Boston, MA 02115; and Section of\r Hematology\/Oncology, University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nika N.","family":"Danial","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and Departments\r of Pathology and Medicine, Harvard Medical School and Dana\u2013Farber Cancer\r Institute, Boston, MA 02115; Division of\r Neuroscience, Children's Hospital Boston and Department of Neurobiology,\r Harvard Medical School, Boston, MA 02115; School\r of Biological Sciences, University of Manchester, Manchester M13 9PT, United\r Kingdom; Department of Pathology, Brigham and\r Women's Hospital, Boston, MA 02115; and Section of\r Hematology\/Oncology, University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Gilmore","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and Departments\r of Pathology and Medicine, Harvard Medical School and Dana\u2013Farber Cancer\r Institute, Boston, MA 02115; Division of\r Neuroscience, Children's Hospital Boston and Department of Neurobiology,\r Harvard Medical School, Boston, MA 02115; School\r of Biological Sciences, University of Manchester, Manchester M13 9PT, United\r Kingdom; Department of Pathology, Brigham and\r Women's Hospital, Boston, MA 02115; and Section of\r Hematology\/Oncology, University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery L.","family":"Kutok","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and Departments\r of Pathology and Medicine, Harvard Medical School and Dana\u2013Farber Cancer\r Institute, Boston, MA 02115; Division of\r Neuroscience, Children's Hospital Boston and Department of Neurobiology,\r Harvard Medical School, Boston, MA 02115; School\r of Biological Sciences, University of Manchester, Manchester M13 9PT, United\r Kingdom; Department of Pathology, Brigham and\r Women's Hospital, Boston, MA 02115; and Section of\r Hematology\/Oncology, University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Le Beau","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and Departments\r of Pathology and Medicine, Harvard Medical School and Dana\u2013Farber Cancer\r Institute, Boston, MA 02115; Division of\r Neuroscience, Children's Hospital Boston and Department of Neurobiology,\r Harvard Medical School, Boston, MA 02115; School\r of Biological Sciences, University of Manchester, Manchester M13 9PT, United\r Kingdom; Department of Pathology, Brigham and\r Women's Hospital, Boston, MA 02115; and Section of\r Hematology\/Oncology, University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and Departments\r of Pathology and Medicine, Harvard Medical School and Dana\u2013Farber Cancer\r Institute, Boston, MA 02115; Division of\r Neuroscience, Children's Hospital Boston and Department of Neurobiology,\r Harvard Medical School, Boston, MA 02115; School\r of Biological Sciences, University of Manchester, Manchester M13 9PT, United\r Kingdom; Department of Pathology, Brigham and\r Women's Hospital, Boston, MA 02115; and Section of\r Hematology\/Oncology, University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley J.","family":"Korsmeyer","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and Departments\r of Pathology and Medicine, Harvard Medical School and Dana\u2013Farber Cancer\r Institute, Boston, MA 02115; Division of\r Neuroscience, Children's Hospital Boston and Department of Neurobiology,\r Harvard Medical School, Boston, MA 02115; School\r of Biological Sciences, University of Manchester, Manchester M13 9PT, United\r Kingdom; Department of Pathology, Brigham and\r Women's Hospital, Boston, MA 02115; and Section of\r Hematology\/Oncology, University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2003,7,22]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.22.2859"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90411-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059108"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1081208"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00320-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/23730"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/415922a"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00127-7"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81382-3"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(05)00012-2"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80405-5"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5338.687"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80469-4"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.171301998"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5443.1358"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00310-9"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90174-8"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/349254a0"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/88815"},{"key":"e_1_3_2_20_2","first-page":"51","volume":"152","year":"1998","unstructured":"Kitada, S., Krajewska, M., Zhang, X., Scudiero, D., Zapata, J. 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