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U.S.A."],"published-print":{"date-parts":[[2016,6,28]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Despite intense interest over a period of decades, mechanisms of allelic exclusion have remained unsolved mysteries in the field of eukaryotic gene expression control. Parasitic African trypanosomes express variant surface glycoproteins (VSGs) in a monoallelic fashion and have long been a paradigm for studies in this area. We used an RNA interference screen for loss of exclusion and identified and characterized VSG exclusion 1 (VEX1). VEX1 sequestration restricts expression and prevents the simultaneous establishment of more than one active\n                    <jats:italic>VSG<\/jats:italic>\n                    gene. VEX1 also appears to reinforce sequestration-based exclusion through homology-dependent repression. Our results indicate a \u201cwinner-takes-all\u201d mechanism that allows parasitic trypanosomes to express just one\n                    <jats:italic>VSG<\/jats:italic>\n                    gene at a time.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1600344113","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:25:24Z","timestamp":1464222324000},"page":"7225-7230","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":116,"title":["VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes"],"prefix":"10.1073","volume":"113","author":[{"given":"Lucy","family":"Glover","sequence":"first","affiliation":[{"name":"Division of Biological Chemistry &amp; Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"Division of Biological Chemistry &amp; Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8621-4920","authenticated-orcid":false,"given":"Sam","family":"Alsford","sequence":"additional","affiliation":[{"name":"Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Horn","sequence":"additional","affiliation":[{"name":"Division of Biological Chemistry &amp; Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,5,25]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.molbiopara.2014.05.001","article-title":"Antigenic variation in African trypanosomes","volume":"195","author":"Horn D","year":"2014","unstructured":"D Horn, Antigenic variation in African trypanosomes. 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