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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,7,26]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Outbreaks of food-borne infections with\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    can result in high mortality. Using a model of recombinant\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    that models human infection in mice, we show that\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    -specific memory \u03b3\u03b4 T cells in fact represent a resident memory (Trm) population in the mesenteric lymph node that secrete IL-17A and cluster with\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    replication foci after secondary infection. Furthermore \u03b3\u03b4 Trms mediate the intranodal migration and redistribution of myeloid cells, which was necessary to contain the spread and growth of\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    . Our findings demonstrate how \u03b3\u03b4 Trm cells orchestrate pathogen-induced innate immune responses. These observations provide the rationale for designing novel vaccination strategies to harness the ability of \u03b3\u03b4 Trm cells to provide protection against intestinal pathogens.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1600713113","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T03:22:27Z","timestamp":1468293747000},"page":"8502-8507","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":74,"title":["IL-17A\u2013producing resident memory \u03b3\u03b4 T cells orchestrate the innate immune response to secondary oral\n                    <i>Listeria monocytogenes<\/i>\n                    infection"],"prefix":"10.1073","volume":"113","author":[{"given":"Pablo A.","family":"Romagnoli","sequence":"first","affiliation":[{"name":"Department of Immunology, UCONN Health, Farmington, CT 06030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian S.","family":"Sheridan","sequence":"additional","affiliation":[{"name":"Department of Immunology, UCONN Health, Farmington, CT 06030;"},{"name":"Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794-5120;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quynh-Mai","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Immunology, UCONN Health, Farmington, CT 06030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Lefran\u00e7ois","sequence":"additional","affiliation":[{"name":"Department of Immunology, UCONN Health, Farmington, CT 06030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal M.","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Immunology, UCONN Health, Farmington, CT 06030;"},{"name":"Department of Pediatrics, UCONN Health, Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,7,11]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nri3384","article-title":"Six-of-the-best: Unique contributions of \u03b3\u03b4 T cells to immunology","volume":"13","author":"Vantourout P","year":"2013","unstructured":"P Vantourout, A Hayday, Six-of-the-best: Unique contributions of \u03b3\u03b4 T cells to immunology. 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