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U.S.A."],"published-print":{"date-parts":[[2016,4,19]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>There are no Food and Drug Administration approved drugs available for preventing or treating Argentine hemorrhagic fever (AHF), and the current treatment option is limited to administration of immune plasma. With the expanding clinical use of monoclonal antibodies (mAbs) for acute and chronic conditions, it has become clear that mAbs offer a highly specific, potent, and generally safe drug platform for antivirals, and may be a useful alternative to immune plasma. Here, we show that mAbs are effective in the Junin virus guinea pig model and likely to be an economical therapy for AHF.<\/jats:p>","DOI":"10.1073\/pnas.1600996113","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T23:51:28Z","timestamp":1459813888000},"page":"4458-4463","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":67,"title":["Monoclonal antibody therapy for Junin virus infection"],"prefix":"10.1073","volume":"113","author":[{"given":"Larry","family":"Zeitlin","sequence":"first","affiliation":[{"name":"Mapp Biopharmaceutical, Inc., San Diego, CA 92121;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan B.","family":"Geisbert","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555;"},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Deer","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555;"},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla A.","family":"Fenton","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555;"},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ognian","family":"Bohorov","sequence":"additional","affiliation":[{"name":"Mapp Biopharmaceutical, Inc., San Diego, CA 92121;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Bohorova","sequence":"additional","affiliation":[{"name":"Mapp Biopharmaceutical, Inc., San Diego, CA 92121;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Goodman","sequence":"additional","affiliation":[{"name":"Mapp Biopharmaceutical, Inc., San Diego, CA 92121;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do","family":"Kim","sequence":"additional","affiliation":[{"name":"Mapp Biopharmaceutical, Inc., San Diego, CA 92121;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hiatt","sequence":"additional","affiliation":[{"name":"Mapp Biopharmaceutical, Inc., San Diego, CA 92121;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Pauly","sequence":"additional","affiliation":[{"name":"Mapp Biopharmaceutical, Inc., San Diego, CA 92121;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Velasco","sequence":"additional","affiliation":[{"name":"Mapp Biopharmaceutical, Inc., San Diego, CA 92121;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Whaley","sequence":"additional","affiliation":[{"name":"Mapp Biopharmaceutical, Inc., San Diego, CA 92121;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Altmann","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Natural Resources and Applied Life Sciences, 1190 Vienna, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Gruber","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Natural Resources and Applied Life Sciences, 1190 Vienna, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herta","family":"Steinkellner","sequence":"additional","affiliation":[{"name":"Department of Applied Genetics and Cell Biology, University of Natural Resources and Applied Life Sciences, 1190 Vienna, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna N.","family":"Honko","sequence":"additional","affiliation":[{"name":"Virology Division, US Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana I.","family":"Kuehne","sequence":"additional","affiliation":[{"name":"Virology Division, US Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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