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Elucidation and systematic comparison of tonic and activated BCR signaling led to the identification of novel signaling effectors, including ACTN4 and ARFGEF2, which were identified as regulators of BL-cell survival. Beyond its relevance to the understanding of BL pathogenesis and the development of targeted therapies, our study complements the general understanding of BCR-induced processes also in physiological settings.<\/jats:p>","DOI":"10.1073\/pnas.1601053113","type":"journal-article","created":{"date-parts":[[2016,5,7]],"date-time":"2016-05-07T09:32:33Z","timestamp":1462613553000},"page":"5688-5693","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":49,"title":["Elucidation of tonic and activated B-cell receptor signaling in Burkitt\u2019s lymphoma provides insights into regulation of cell survival"],"prefix":"10.1073","volume":"113","author":[{"given":"Jasmin","family":"Corso","sequence":"first","affiliation":[{"name":"Bioanalytical Mass Spectrometry Group, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, 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