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In addition, we discover a role for the SARM1 TIR domain in injury-induced activation of the SARM1 protein, suggesting that this domain contributes to SARM1 regulation in addition to the execution of axon degeneration. These studies identify potential avenues for therapeutic intervention in SARM1-dependent axon destruction pathways.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1601506113","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T20:48:35Z","timestamp":1474922915000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":140,"title":["SARM1-specific motifs in the TIR domain enable NAD\n                    <sup>+<\/sup>\n                    loss and regulate injury-induced SARM1 activation"],"prefix":"10.1073","volume":"113","author":[{"given":"Daniel W.","family":"Summers","sequence":"first","affiliation":[{"name":"Department of Genetics, Washington University in St. Louis, St. Louis, MO 63110;"},{"name":"Department of Developmental Biology, Washington University in St. Louis, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel 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