{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:14:17Z","timestamp":1792653257237,"version":"4.5.0"},"reference-count":35,"publisher":"National Academy of Sciences","issue":"16","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,4,19]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    IL-1 is a pleiotropic cytokine involved in a myriad of autoinflammatory disorders. In proline-serine-threonine phosphatase-interacting protein 2 (\n                    <jats:italic>Pstpip2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>cmo<\/jats:italic>\n                    <\/jats:sup>\n                    ) mice, IL-1\u03b2 provokes autoinflammatory osteomyelitis. Here, we demonstrated the redundant roles of Nod like receptor family, pyrin domain containing 3 (NLRP3) inflammasome with caspase 8 in the processing of IL-1\u03b2 in\n                    <jats:italic>Pstpip2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>cmo<\/jats:italic>\n                    <\/jats:sup>\n                    mice. Identification of redundancy between NLRP3 inflammasome and caspase 8 is fundamental in our understanding of the inflammasomes and alternative modes of IL-1\u03b2 regulation in osteomyelitic disease. Moreover, IL-1\u03b2 signaling connects distinct compartments in promoting the disease, identifying previously unidentified checkpoints that could be targeted for therapeutic purposes in similar disease settings. Thus, our studies have unraveled the complex IL-1\u03b2 regulatory network in vivo in a mouse model of osteomyelitis that will be useful for autoinflammatory diseases in general.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1601636113","type":"journal-article","created":{"date-parts":[[2016,4,7]],"date-time":"2016-04-07T01:26:58Z","timestamp":1459992418000},"page":"4452-4457","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":133,"title":["NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1\u03b2\u2013mediated osteomyelitis"],"prefix":"10.1073","volume":"113","author":[{"given":"Prajwal","family":"Gurung","sequence":"first","affiliation":[{"name":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Burton","sequence":"additional","affiliation":[{"name":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thirumala-Devi","family":"Kanneganti","sequence":"additional","affiliation":[{"name":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,4,6]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1318688111"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13788"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12174"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.20.13587"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-04-425595"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200508091"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.46.30487"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401494"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-204925"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.07.009"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3556"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0000000000000126"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-11-47"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-015-0488-2"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1318685111"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.08.025"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302839"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.01.006"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300645"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202121"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2222"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302549"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri802"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X09359728"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301581"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.11.10.1299"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04517"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.4.1427"},{"key":"e_1_3_3_29_2","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.4049\/jimmunol.159.7.3364","article-title":"Phenotypic and functional characterization of mice that lack the type I receptor for IL-1","volume":"159","author":"Glaccum MB","year":"1997","unstructured":"MB Glaccum, , Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. 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