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Here we demonstrate that only a subset of HLA-DQ alleles mediates EBV entry, indicating that individuals expressing these alleles may offer unique sites for EBV infection and subsequent sequelae. Additionally, the specific site within HLA-DQ determined to be essential for EBV entry is homologous to a site within MHC class I shown by structural studies to bind to the C type-lectin-like natural killer receptor, providing insight into the biochemical nature of the gp42\u2013HLA class II interaction.<\/jats:p>","DOI":"10.1073\/pnas.160171697","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:41:48Z","timestamp":1027680108000},"page":"9252-9257","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":55,"title":["Coreceptor restriction within the HLA-DQ locus for Epstein\u2013Barr virus infection"],"prefix":"10.1073","volume":"97","author":[{"given":"Keith M.","family":"Haan","sequence":"first","affiliation":[{"name":"Department of Microbiology\u2013Immunology, Northwestern University Medical School, Chicago, IL 60611"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Longnecker","sequence":"additional","affiliation":[{"name":"Department of Microbiology\u2013Immunology, Northwestern University Medical School, Chicago, IL 60611"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2000,7,25]]},"reference":[{"key":"e_1_3_3_1_2","first-page":"2397","volume-title":"Fields Virology","author":"Rickinson A","year":"1996","unstructured":"A Rickinson, E Kieff Fields Virology, eds B Fields, D Knipe, P Howley, R Chanock, J Melnick, T Monath, B Roizman, S Straus (Lippincott, Philadelphia) 2, 2397\u20132446 (1996)."},{"key":"e_1_3_3_2_2","first-page":"133","volume-title":"Human Tumor Viruses","author":"Longnecker R","year":"1998","unstructured":"R Longnecker Human Tumor Viruses, ed D McCance (Am. 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