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U.S.A."],"published-print":{"date-parts":[[2016,5,3]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>The bacterial protein FtsZ polymerizes into protofilaments to create the cytokinetic ring responsible for directing cell division. Cellular levels of FtsZ are above the concentration required for Z-ring formation. Hence, FtsZ-binding proteins have evolved that control its spatiotemporal formation. The SlmA protein is one such factor that, when bound to specific chromosomal DNA, inhibits FtsZ polymerization to prevent Z rings from forming through the bacterial chromosome. This inhibition depends on complex formation between SlmA-DNA and the FtsZ C-terminal domain (CTD). Here we describe SlmA\u2013DNA\u2013FtsZ CTD structures. These structures and complementary biochemistry unveil the molecular basis for the unique requirement that SlmA be DNA-bound to interact with FtsZ, a mechanism that appears to be conserved among SlmA-containing bacteria.<\/jats:p>","DOI":"10.1073\/pnas.1602327113","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T00:14:08Z","timestamp":1461024848000},"page":"4988-4993","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":59,"title":["Structures of the nucleoid occlusion protein SlmA bound to DNA and the C-terminal domain of the cytoskeletal protein FtsZ"],"prefix":"10.1073","volume":"113","author":[{"given":"Maria A.","family":"Schumacher","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,4,18]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/354161a0","article-title":"FtsZ ring structure associated with division in Escherichia coli","volume":"354","author":"Bi EF","year":"1991","unstructured":"EF Bi, J Lutkenhaus, FtsZ ring structure associated with division in Escherichia coli. 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