{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:44:02Z","timestamp":1788410642973,"version":"build-2803163510"},"reference-count":53,"publisher":"National Academy of Sciences","issue":"13","license":[{"start":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T00:00:00Z","timestamp":1473984000000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/www.pnas.org\/preview_site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91439205"],"award-info":[{"award-number":["91439205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31330037"],"award-info":[{"award-number":["31330037"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["DK094956"],"award-info":[{"award-number":["DK094956"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["DK104072"],"award-info":[{"award-number":["DK104072"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2012CB517600"],"award-info":[{"award-number":["2012CB517600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swedish Science Council","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/100000928","name":"Robert A. Welch Foundation","doi-asserted-by":"crossref","award":["E-0004"],"award-info":[{"award-number":["E-0004"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,3,29]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>The soluble (pro)renin receptor (sPRR) is produced by protease-mediated cleavage of PRR and is elevated under certain pathological conditions. To our knowledge, no prior studies have reported the biological function of sPRR in general or the antidiuretic function of the soluble protein in particular. Here we describe a previously unreported role of sPRR in the enhancement of renal aquaporin 2 (AQP2) expression and urine-concentrating capability. We further show that sPRR acts via frizzled class receptor 8-depdendent \u03b2-catenin signaling to increase AQP2 expression in the collecting duct cells. These findings offer an unreported insight into the physiological role of sPRR in regulating fluid homeostasis. In addition, we found that liver X receptor activation by TO901317 resulted in diabetes insipidus because of the inhibition of renal PRR expression.<\/jats:p>","DOI":"10.1073\/pnas.1602397113","type":"journal-article","created":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T23:54:27Z","timestamp":1458172467000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":95,"title":["Soluble (pro)renin receptor via \u03b2-catenin enhances urine concentration capability as a target of liver X receptor"],"prefix":"10.1073","volume":"113","author":[{"given":"Xiaohan","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112;"},{"name":"Veterans Affairs Medical Center, Salt Lake City, UT 84108;"},{"name":"Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112;"},{"name":"Veterans Affairs Medical Center, Salt Lake City, UT 84108;"},{"name":"Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanming","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunny","family":"Soodvilai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112;"},{"name":"Veterans Affairs Medical Center, Salt Lake City, UT 84108;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112;"},{"name":"Veterans Affairs Medical Center, Salt Lake City, UT 84108;"},{"name":"Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Su","sequence":"additional","affiliation":[{"name":"Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112;"},{"name":"Veterans Affairs Medical Center, Salt Lake City, UT 84108;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin T.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112;"},{"name":"Veterans Affairs Medical Center, Salt Lake City, UT 84108;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557;"},{"name":"Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Feng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL 33620;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-\u00c5ke","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Biology and Biochemistry, University of Houston, Houston, TX 77004"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112;"},{"name":"Veterans Affairs Medical Center, Salt Lake City, UT 84108;"},{"name":"Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,3,16]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-010-0172-9"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.197418"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214276"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.224667"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.127258"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.284"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2741\/E640"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.04.176"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-013-0803-y"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-4139"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2014.46"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02217"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.128645"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015050592"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00126.2015"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2005.01.003"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(99)00555-7"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1168974"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.16.1.459"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5484.1524"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.159"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00341.2011"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00283.2012"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.190108"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.196303"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08356"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5393.1484"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00024.2001"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.253"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005040371"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2118-8"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24594"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1200588109"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012010022"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03654"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00052.2014"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1179802"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.5527\/wjn.v3.i4.302"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20130307"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-012-1105-z"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063835"},{"key":"e_1_3_3_42_2","first-page":"F443","article-title":"Adenylate cyclase-coupled vasopressin receptor activates AQP2 promoter via a dual effect on CRE and AP1 elements","volume":"272","author":"Yasui M","year":"1997","unstructured":"M Yasui, SM Zelenin, G Celsi, A Aperia, Adenylate cyclase-coupled vasopressin receptor activates AQP2 promoter via a dual effect on CRE and AP1 elements. Am J Physiol 272, F443\u2013F450 (1997).","journal-title":"Am J Physiol"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.0224.2001"},{"key":"e_1_3_3_44_2","article-title":"Activation of ENaC in collecting duct cells by prorenin and its receptor PRR: Involvement of Nox4-derived hydrogen peroxide","author":"Lu X","year":"2015","unstructured":"X Lu, , Activation of ENaC in collecting duct cells by prorenin and its receptor PRR: Involvement of Nox4-derived hydrogen peroxide. Am J Physiol Renal Physiol, 2015).","journal-title":"Am J Physiol Renal Physiol"},{"key":"e_1_3_3_45_2","first-page":"115","article-title":"Vasopressin and desmopressin in central diabetes insipidus: adverse effects and clinical considerations","volume":"2","author":"Kim RJ","year":"2004","unstructured":"RJ Kim, C Malattia, M Allen, Jr T Moshang, M Maghnie, Vasopressin and desmopressin in central diabetes insipidus: adverse effects and clinical considerations. Pediatr Endocrinol Rev 2, 115\u2013123 (2004).","journal-title":"Pediatr Endocrinol Rev"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.23.1_Suppl.I8"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.19.1_Suppl.I96"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197506192922506"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(71)90152-5"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501744102"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1278"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.7"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0514-1"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1602397113","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1602397113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T01:51:57Z","timestamp":1649814717000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1602397113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,16]]},"references-count":53,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2016,3,29]]}},"alternative-id":["10.1073\/pnas.1602397113"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1602397113","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,16]]},"assertion":[{"value":"2016-03-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}