{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:34:57Z","timestamp":1790674497297,"version":"4.1.0"},"reference-count":68,"publisher":"National Academy of Sciences","issue":"38","license":[{"start":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T00:00:00Z","timestamp":1473120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/100000053","name":"HHS | NIH | National Eye Institute","doi-asserted-by":"publisher","award":["PN2EY016525"],"award-info":[{"award-number":["PN2EY016525"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001167","name":"Larry L. Hillblom Foundation","doi-asserted-by":"publisher","award":["not available"],"award-info":[{"award-number":["not available"]}],"id":[{"id":"10.13039\/100001167","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,9,20]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Degeneration of the corticostriatal circuit is a key neuropathological and clinical feature of Huntington\u2019s disease (HD). To define disease mechanisms and explore treatments, we recreated the corticostriatal circuit in microfluidic chambers using neurons from the BACHD mouse model of HD and WT controls. We showed that expression of mutant huntingtin (mHTT) induced defects in brain-derived neurotrophic factor (BDNF) transport in BACHD cortical axons that resulted in atrophy of striatal target neurons. Introducing subunits of the cytosolic chaperonin T-complex 1 (TCP-1) ring complex (TRiC) into BACHD cortical neurons reduced mHTT, rescued defects in BDNF transport, and normalized the size of striatal neurons. These findings encourage studies to explore a role for TRiC reagents as possible treatments for HD.<\/jats:p>","DOI":"10.1073\/pnas.1603020113","type":"journal-article","created":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T21:55:26Z","timestamp":1473198926000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":99,"title":["TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington\u2019s disease"],"prefix":"10.1073","volume":"113","author":[{"given":"Xiaobei","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Qiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Ding","sequence":"additional","affiliation":[{"name":"The University of Texas M. D. Anderson Cancer Center, Houston, TX 77054;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Overman","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior, University of California, Irvine, CA 92697;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice L.","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior, University of California, Irvine, CA 92697;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah H.","family":"Shahmoradian","sequence":"additional","affiliation":[{"name":"National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wah","family":"Chiu","sequence":"additional","affiliation":[{"name":"National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior, University of California, Irvine, CA 92697;"},{"name":"Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengbiao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Mobley","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,9,6]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70245-3"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199805000-00001"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2007.11.011"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06022"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1427.018"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3514"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01721-5"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2005.01.001"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059581"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-45106-5_9"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/39885"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2007.01.003"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04590.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2461-07.2007"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1197-04.2004"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.24510"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.70.1.603"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/jsbi.2001.4380"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2004.09.015"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1477"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/843206"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1478"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.13.2009"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00594-4"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913774107"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1222663110"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.655373"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0857-08.2008"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1637-10.2010"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000132965.14653.D1"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3920-03.2004"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1212899109"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-17-06856.2003"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042785"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0721930.x"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn2038"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201201038"},{"key":"e_1_3_3_38_2","first-page":"51899","article-title":"Real-time imaging of axonal transport of quantum dot-labeled BDNF in primary neurons","author":"Zhao X","year":"2014","unstructured":"X Zhao, , Real-time imaging of axonal transport of quantum dot-labeled BDNF in primary neurons. J Vis Exp, pp. 51899 (2014).","journal-title":"J Vis Exp"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118379"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.11.020"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/neu.10315"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43992"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3379"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2033-12.2013"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610628104"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M509806200"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2009.01.005"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e10-03-0233"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2628045100"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.4.503"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2009"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-2-8"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.03.025"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq548"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2812-14.2015"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.06.018"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.05.024"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1371\/currents.RRN1255"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.05.009"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80623-6"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-22-08772.2001"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0805-736"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-19-07268.2000"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2007.09.023"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1700"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0895-12.2012"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-15-05406.2001"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80514-0"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1603020113","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1603020113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T01:10:52Z","timestamp":1649812252000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1603020113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,6]]},"references-count":68,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2016,9,20]]}},"alternative-id":["10.1073\/pnas.1603020113"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1603020113","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,6]]},"assertion":[{"value":"2016-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}