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We demonstrate that cytotoxic CD8 T cells, but not Th1 CD4 cells, are able to target and destroy orexinergic neurons. This selective neuronal loss is responsible for clinical signs mimicking human narcolepsy. By identifying potential immune effectors of the immunopathological process in narcolepsy, these findings offer a rationale for the use of immunotherapies.<\/jats:p>","DOI":"10.1073\/pnas.1603325113","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T22:29:15Z","timestamp":1473719355000},"page":"10956-10961","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":148,"title":["CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice"],"prefix":"10.1073","volume":"113","author":[{"given":"Rapha\u00ebl","family":"Bernard-Valnet","sequence":"first","affiliation":[{"name":"Center for Pathophysiology Toulouse Purpan, Universit\u00e9 Toulouse III, INSERM U1043, CNRS UMR 5282, 31024 Toulouse, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Yshii","sequence":"additional","affiliation":[{"name":"Center for Pathophysiology Toulouse 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