{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:51:34Z","timestamp":1781106694424,"version":"3.54.1"},"reference-count":72,"publisher":"National Academy of Sciences","issue":"15","license":[{"start":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:00:00Z","timestamp":1475020800000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/www.pnas.org\/preview_site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["81070689"],"award-info":[{"award-number":["81070689"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["AG40132"],"award-info":[{"award-number":["AG40132"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["AG23176"],"award-info":[{"award-number":["AG23176"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR65932"],"award-info":[{"award-number":["AR65932"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR67066"],"award-info":[{"award-number":["AR67066"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,4,12]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Notch is a critical regulator of skeletal development, but its role in remodeling of the adult skeleton is unclear. Using genetically modified mice, we show that Notch stimulates skeletal mineralization by bone-building osteoblasts. Thus, overexpression of the Notch intracellular domain in mice results in an increase in bone mass, prevents bone loss following ovariectomy and during aging, and promotes fracture healing. Notch is therefore a potential therapeutic target for conditions of bone loss, including osteoporosis.<\/jats:p>","DOI":"10.1073\/pnas.1603399113","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T22:48:48Z","timestamp":1459205328000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":45,"title":["Anabolic actions of Notch on mature bone"],"prefix":"10.1073","volume":"113","author":[{"given":"Peng","family":"Liu","sequence":"first","affiliation":[{"name":"The Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, NY 10029;"},{"name":"State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Sichuan 610041, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Ping","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Sichuan 610041, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demao","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Sichuan 610041, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Department of Genetics, Yale School of Medicine, New Haven, CT 06520;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Stomatology, Wuhan University, Wuhan 430079, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoting","family":"Ji","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, NY 10029;"},{"name":"School of Stomatology, Wuhan University, Wuhan 430079, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Lou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Sichuan 610041, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanyuan","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Sichuan 610041, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Lu","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Stachnik","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingru","family":"Bai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Sichuan 610041, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengguo","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liaoran","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Sichuan 610041, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Sichuan 610041, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"New","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Mount Sinai School of Medicine, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Reconstructive Sciences, School of Dental Medicine, University of Connecticut School of Medicine, Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Yuen","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mone","family":"Zaidi","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, NY 10029;"},{"name":"Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,3,28]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(10)92001-2"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(10)92008-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.7.1046"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10140"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.15.3415"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/35016111"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.21.2801"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.5.723"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.8.1391"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq529"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.7.1795"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.60"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1716"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1712"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0140"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.115"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.470492"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-013-0145-4"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.05.027"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/stke.117pe17"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06090"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1164"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80244-5"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.1.15"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708600404"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080809"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.07.010"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/15.suppl_6.66"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.129.5.1421"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(10)92012-7"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02982106"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.25.030702.130823"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00689-X"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(02)00003-8"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.8.2431.408k33_2431_2448"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201540188"},{"key":"e_1_3_3_37_2","first-page":"513","article-title":"[Spondylocostal dysostosis: A rare genetic disease]","volume":"59","author":"Beine O","year":"2004","unstructured":"O Beine, , [Spondylocostal dysostosis: A rare genetic disease]. Rev Med Liege 59, 513\u2013516 (2004).","journal-title":"Rev Med Liege"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/74307"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-013-2298-5"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.779"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/387288a0"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e11-02-0139"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000662"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1133141"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20850"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/gene.10081"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.5.1533"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508370200"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.7.1228"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.06.025"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21518"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1593"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.154"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00571-2"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.182"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1305224"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2014.01.023"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.173"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-005-5199-4"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-03-00834.2001"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710156104"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(10)77007-5"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.051"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.365049"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.4A6401.2005"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.141"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.10.e48"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5446.1946"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16198"},{"key":"e_1_3_3_70_2","first-page":"345","article-title":"Studies of local bone remodeling. The calvarial injection assay","volume":"80","author":"van \u2019t Hof RJ","year":"2003","unstructured":"RJ van \u2019t Hof, CE Clarkin, KJ Armour, Studies of local bone remodeling. The calvarial injection assay. Methods Mol Med 80, 345\u2013351 (2003).","journal-title":"Methods Mol Med"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.8.1497"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.06.039"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1603399113","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1603399113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:56:16Z","timestamp":1649811376000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1603399113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,28]]},"references-count":72,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2016,4,12]]}},"alternative-id":["10.1073\/pnas.1603399113"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1603399113","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,28]]},"assertion":[{"value":"2016-03-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}