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In this study, we identify RING finger protein 122 (RNF122) as an E3 ligase that directly binds to RIG-I to induce K48-linked ubiquitination of RIG-I and mediate RIG-I degradation, consequently suppressing RIG-I\u2013triggered antiviral innate immune response. RNF122 expression is upregulated by innate stimuli, and then acts as a feedback-negative regulator of RIG-I signaling to restrain type I IFN overproduction. Our study adds insight into the role of E3 ligases in the control of antiviral innate immunity.<\/jats:p>","DOI":"10.1073\/pnas.1604277113","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T22:53:38Z","timestamp":1470783218000},"page":"9581-9586","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":120,"title":["RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation"],"prefix":"10.1073","volume":"113","author":[{"given":"Wendie","family":"Wang","sequence":"first","affiliation":[{"name":"National Key Laboratory of Medical Molecular Biology, Department of Immunology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghong","family":"Jiang","sequence":"additional","affiliation":[{"name":"National Key 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