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U.S.A."],"published-print":{"date-parts":[[2016,8,16]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Organ fibrosis is a major cause of global morbidity and mortality. It is driven by chronic inflammation and associated oxidative stress with depletion of cellular antioxidant defenses. We demonstrate a pathway in which the evolutionarily conserved receptor stabilin-1 on tissue-infiltrating macrophages provides a second-line defense to prevent tissue damage from oxidative stress. Stabilin-1\n                    <jats:sup>+<\/jats:sup>\n                    monocytes take up malondialdehyde-LDL (MDA-LDL), a major product of oxidative lipid peroxidation, to form ceroid-laden macrophages. Through the uptake of MDA-LDL, stabilin-1 suppresses production of the profibrogenic chemokine CCL3 and prevents excessive collagen deposition in experimental models of liver fibrosis. We propose that macrophage stabilin-1 is a critical defense against oxidative tissue damage and thereby maintains tissue homeostasis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1604780113","type":"journal-article","created":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T23:08:43Z","timestamp":1469833723000},"page":"9298-9303","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":124,"title":["Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury"],"prefix":"10.1073","volume":"113","author":[{"given":"Pia","family":"Rantakari","sequence":"first","affiliation":[{"name":"MediCity Research Laboratory and Department of Medical Microbiology and Immunology, University of Turku, FI-20520, Turku, Finland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Patten","sequence":"additional","affiliation":[{"name":"National 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