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Restoration of either\n                    <jats:italic>Pten<\/jats:italic>\n                    -mediated cell-cycle transition or Hedgehog signaling restored cardiac septation in\n                    <jats:italic>Gata4<\/jats:italic>\n                    -mutant mice, suggesting that defects in both pathways are required for disease causation. This work generates a working model for understanding the molecular basis of human congenital heart disease caused by dominant transcription factor mutations.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1605137114","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T21:05:30Z","timestamp":1486415130000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":71,"title":["Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation"],"prefix":"10.1073","volume":"114","author":[{"given":"Lun","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Basic Sciences, University of North Dakota, Grand Forks, ND 58202;"},{"name":"Department of Gerontology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, 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