{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:36:08Z","timestamp":1793662568405,"version":"4.5.1"},"reference-count":38,"publisher":"National Academy of Sciences","issue":"37","license":[{"start":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:00:00Z","timestamp":1488240000000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/www.pnas.org\/preview_site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/100000053","name":"HHS | NIH | National Eye Institute","doi-asserted-by":"publisher","award":["EY017001"],"award-info":[{"award-number":["EY017001"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,9,13]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Discovering characteristics of a signal that indicates to medical experts the presence of cancer in a noninvasive screening technique in a blink of an eye has implications for improving cancer detection. Here we report two surprising facts about this signal. First, it is much stronger in the high spatial frequencies (fine detail) than in the low frequencies. Second, it is widely distributed, with signal being present well away from the actual visible locus of disease even in the breast contralateral to visible signs of disease. Although this signal is not, in itself, definitive, it has the potential to be used in automated aids to medical screening and incorporated into training protocols for medical experts, speeding up and improving cancer detection.<\/jats:p>","DOI":"10.1073\/pnas.1606187113","type":"journal-article","created":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T22:33:17Z","timestamp":1472509997000},"page":"10292-10297","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":70,"title":["A half-second glimpse often lets radiologists identify breast cancer cases even when viewing the mammogram of the opposite breast"],"prefix":"10.1073","volume":"113","author":[{"given":"Karla K.","family":"Evans","sequence":"first","affiliation":[{"name":"Department of Psychology, University of York, Heslington, York YO10 5DD, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara Miner","family":"Haygood","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Radiology, York Teaching Hospital, York YO31 8HE, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Culpan","sequence":"additional","affiliation":[{"name":"Division of Biomedical Imaging, University of Leeds, Leeds LS2 9JT, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy M.","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Harvard Medical School, Boston, MA 02115;"},{"name":"Department of Radiology, Harvard Medical School, Boston, MA 02115;"},{"name":"Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,8,29]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1037\/h0037158"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/253437a0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.092277599"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2005.10.002"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3758\/s13423-013-0459-3"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.54.1.41"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21166"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.184.3.1509041"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.234025083"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh067"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.15.14312"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/116.3.527"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3758\/BF03207377"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.166.2.3336720"},{"key":"e_1_3_3_15_2","first-page":"106","volume-title":"Medical Imaging 1995","author":"Mugglestone MD","year":"1995","unstructured":"MD Mugglestone, AG Gale, HC Cowley, ARM Wilson, Diagnostic performance on briefly presented mammographic images. Medical Imaging 1995, ed HL Kundel (International Society for Optics and Photonics, San Diego), pp. 106\u2013115 (1995)."},{"key":"e_1_3_3_16_2","first-page":"572","volume-title":"Eye Movements: From Psychology to Cognition","author":"Nodine CF","year":"1987","unstructured":"CF Nodine, HL Kundel, The cognitive side of visual search in radiology. Eye Movements: From Psychology to Cognition, eds JK O'Regan, A Levy-Shoen (Elsevier Science, Amsterdam), pp. 572\u2013658 (1987)."},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3758\/BF03199899"},{"key":"e_1_3_3_18_2","first-page":"528","volume-title":"Oxford Handbook on Eye Movements","author":"Reingold EM","year":"2011","unstructured":"EM Reingold, H Sheridan, Eye movements and visual expertise in chess and medicine. Oxford Handbook on Eye Movements, eds SP Liversedge, ID Gilchrist, S Everling (Oxford Univ Press, Oxford), pp. 528\u2013550 (2011)."},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/13506280500195250"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195189193.003.0008"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2010.12.001"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9280.00327"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(02)00596-5"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1167\/11.12.18"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012375731-9\/50045-8"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(06)55002-2"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1388"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compmedimag.2014.03.001"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2012.04.018"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9280.1994.tb00500.x"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0623"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0010-0285(77)90012-3"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.112.1.24"},{"key":"e_1_3_3_34_2","first-page":"424","article-title":"Relationships between computer-extracted mammographic texture pattern features and BRCA1\/2 mutation status: A cross-sectional study","volume":"16","author":"Gierach GL","year":"2014","unstructured":"GL Gierach, , Relationships between computer-extracted mammographic texture pattern features and BRCA1\/2 mutation status: A cross-sectional study. Breast Cancer Res 16, 424 (2014).","journal-title":"Breast Cancer Res"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.10187"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr492"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0034"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2422051997"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1606187113","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1606187113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T01:37:53Z","timestamp":1649813873000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1606187113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,29]]},"references-count":38,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2016,9,13]]}},"alternative-id":["10.1073\/pnas.1606187113"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1606187113","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,29]]},"assertion":[{"value":"2016-08-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}