{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:54:24Z","timestamp":1787241264053,"version":"build-2736575974"},"reference-count":68,"publisher":"National Academy of Sciences","issue":"41","license":[{"start":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:00:00Z","timestamp":1475020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["DP2-OD006511"],"award-info":[{"award-number":["DP2-OD006511"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["U01-HG007708-03"],"award-info":[{"award-number":["U01-HG007708-03"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL103428"],"award-info":[{"award-number":["R01 HL103428"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["DP1 HL123271"],"award-info":[{"award-number":["DP1 HL123271"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["K12-HD000850"],"award-info":[{"award-number":["K12-HD000850"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["K99-HL130523"],"award-info":[{"award-number":["K99-HL130523"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["T32-HL094274"],"award-info":[{"award-number":["T32-HL094274"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,10,11]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Most genetic studies and clinical genetic testing do not look for the possibility of mosaic variation. The genetic form of long-QT syndrome (LQTS) can result in life-threatening arrhythmias, but 30% of patients do not have a genetic diagnosis. We performed deep characterization of a mosaic variant in an infant with perinatal LQTS and developed a computational model showing how abnormal cellular repolarization in only 8% of heart cells may cause arrhythmia. Finally we looked at the prevalence of mosaicism among patients with LQTS; in a population of 7,500 individuals we found evidence of pathogenic early somatic mosaicism in approximately 0.17% of LQTS patients without a genetic diagnosis. Together these data establish an unreported mechanism for LQTS and other genetic arrhythmias.<\/jats:p>","DOI":"10.1073\/pnas.1607187113","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T23:38:48Z","timestamp":1475105928000},"page":"11555-11560","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":43,"title":["Early somatic mosaicism is a rare cause of long-QT syndrome"],"prefix":"10.1073","volume":"113","author":[{"given":"James Rush","family":"Priest","sequence":"first","affiliation":[{"name":"Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Child Health Research Institute, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Division of Pediatric Cardiology, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Gawad","sequence":"additional","affiliation":[{"name":"Child Health Research Institute, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Division of Pediatric Hematology-Oncology, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristopher M.","family":"Kahlig","sequence":"additional","affiliation":[{"name":"Department of Biology, Cardiovascular Therapeutic Area, Gilead Sciences, Fremont, CA 94555;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph K.","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218;"},{"name":"Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"O\u2019Hara","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9048-1239","authenticated-orcid":false,"given":"Patrick M.","family":"Boyle","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218;"},{"name":"Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridharan","family":"Rajamani","sequence":"additional","affiliation":[{"name":"Department of Biology, Cardiovascular Therapeutic Area, Gilead Sciences, Fremont, CA 94555;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Clark","sequence":"additional","affiliation":[{"name":"Personalis, Inc., Menlo Park, CA 94025;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah T. K.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Personalis, Inc., Menlo Park, CA 94025;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Ceresnak","sequence":"additional","affiliation":[{"name":"Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Child Health Research Institute, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Division of Pediatric Cardiology, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Harris","sequence":"additional","affiliation":[{"name":"Personalis, Inc., Menlo Park, CA 94025;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Boyle","sequence":"additional","affiliation":[{"name":"Personalis, Inc., Menlo Park, CA 94025;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick E.","family":"Dewey","sequence":"additional","affiliation":[{"name":"Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Malloy-Walton","sequence":"additional","affiliation":[{"name":"Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Child Health Research Institute, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Division of Pediatric Cardiology, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyla","family":"Dunn","sequence":"additional","affiliation":[{"name":"Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Lucile Packard Children\u2019s Hospital Heart Center, Palo Alto, CA 94304;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Grove","sequence":"additional","affiliation":[{"name":"Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2746-0202","authenticated-orcid":false,"given":"Marco V.","family":"Perez","sequence":"additional","affiliation":[{"name":"Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma F.","family":"Neff","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Chen","sequence":"additional","affiliation":[{"name":"Personalis, Inc., Menlo Park, CA 94025;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhide","family":"Maeda","sequence":"additional","affiliation":[{"name":"Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Division of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Dubin","sequence":"additional","affiliation":[{"name":"Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Child Health Research Institute, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Division of Pediatric Cardiology, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz","family":"Belardinelli","sequence":"additional","affiliation":[{"name":"Department of Biology, Cardiovascular Therapeutic Area, Gilead Sciences, Fremont, CA 94555;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"West","sequence":"additional","affiliation":[{"name":"Personalis, Inc., Menlo Park, CA 94025;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Antolik","sequence":"additional","affiliation":[{"name":"Cardiogenetic Testing Services, GeneDx, Gaithersburg, MD 20877;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Macaya","sequence":"additional","affiliation":[{"name":"Cardiogenetic Testing Services, GeneDx, Gaithersburg, MD 20877;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Quertermous","sequence":"additional","affiliation":[{"name":"Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia A.","family":"Trayanova","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218;"},{"name":"Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Quake","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Department of Applied Physics, Stanford University, Stanford, CA 94305;"},{"name":"Howard Hughes Medical Research Institute, Stanford University School of Medicine, Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Euan A.","family":"Ashley","sequence":"additional","affiliation":[{"name":"Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Child Health Research Institute, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,9,28]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3424"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.05.008"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.961227"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11725"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314432"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052800"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv033"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e32833846b3"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2013.08.001"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-2941"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000130666.81539.9E"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34223"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000618"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.05.014"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2012.0118"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.114132"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.02.035"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.3219"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.11.021"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000174429.00987.17"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.08.010"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.027995"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eun202"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-301784"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.07.007"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097720"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eun248"},{"key":"e_1_3_3_28_2","doi-asserted-by":"crossref","unstructured":"VM Narasimhan A direct multi-generational estimate of the human mutation rate from autozygous segments seen in thousands of parentally related individuals. bioRxiv:059436. (2016).","DOI":"10.1101\/059436"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3469"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2015.249623"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.06.030"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004041"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208594"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.1717"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-015-0221-8"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.92"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.151"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2015.111"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.019475"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2053"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt314"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.107524.110"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07517"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq603"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1089\/cmb.1997.4.311"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm407"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.137323.112"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2011.10.005"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2012-13-9-r50"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2006.03.006"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01589"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.113.088492"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.07.042"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-985X.2010.00676_9.x"},{"key":"e_1_3_3_55_2","doi-asserted-by":"crossref","unstructured":"P Mayo T Hartshorne K Li CNV analysis using TaqMan copy number assays. Curr Protoc Hum Genet Chapter 2: Unit 2.13. (2010).","DOI":"10.1002\/0471142905.hg0213s67"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6107(98)00006-6"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-009-9829-4"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002061"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00794.2003"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.187328"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2002.804597"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2003.09.017"},{"key":"e_1_3_3_63_2","first-page":"3381","article-title":"From mitochondrial ion channels to arrhythmias in the heart: Computational techniques to bridge the spatio-temporal scales","volume":"366","author":"Plank G","year":"2008","unstructured":"G Plank, , From mitochondrial ion channels to arrhythmias in the heart: Computational techniques to bridge the spatio-temporal scales. Philos Trans A Math Phys Eng Sci 366, 3381\u20133409 (2008).","journal-title":"Philos Trans A Math Phys Eng Sci"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(75)90116-7"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2002.3274"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3370"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euq258"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005496"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1607187113","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1607187113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T01:29:21Z","timestamp":1649813361000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1607187113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,28]]},"references-count":68,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2016,10,11]]}},"alternative-id":["10.1073\/pnas.1607187113"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1607187113","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726785642.793536158","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.726785642.793535844","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,28]]},"assertion":[{"value":"2016-09-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}