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We have developed a mouse tumor model that mimics resistance found in human tumors, and we show that intratumoral injections of a high IFN-inducing CpG oligonucleotide, SD-101, can rapidly lead to durable rejection of anti\u2013PD-1 nonresponder tumors and generate systemic immunity to untreated distant-site tumors. The change in tumor microenvironment caused by SD-101 leads to rapid T-cell infiltration and generation of multifunctional CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. These studies provide significant insights into the synergy between PD-1 blockade and local TLR9 activation and provide the experimental support for clinical studies of combination therapy with PD-1 blockade and intratumoral SD-101.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1608555113","type":"journal-article","created":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T21:59:38Z","timestamp":1477951178000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":219,"title":["Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8\n                    <sup>+<\/sup>\n                    T cells"],"prefix":"10.1073","volume":"113","author":[{"given":"Shu","family":"Wang","sequence":"first","affiliation":[{"name":"Discovery, Dynavax Technologies Corporation, Berkeley, CA 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