{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:03:26Z","timestamp":1791270206791,"version":"4.1.0"},"reference-count":65,"publisher":"National Academy of Sciences","issue":"44","license":[{"start":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T00:00:00Z","timestamp":1492560000000},"content-version":"vor","delay-in-days":182,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/100000055","name":"HHS | NIH | National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01-DC03806"],"award-info":[{"award-number":["R01-DC03806"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Neurons that innervate the inner ear originate as neuroblasts in the otic vesicle, the epithelial precursor of the inner ear. Neuroblasts subsequently delaminate from the otic epithelium to complete differentiation near the hindbrain. Despite growing understanding of otic neurogenesis, the mechanism by which neuroblasts delaminate from the otic vesicle is unknown. Here we show that delamination is triggered by\n                    <jats:italic>Goosecoid<\/jats:italic>\n                    (\n                    <jats:italic>Gsc<\/jats:italic>\n                    ), a homeobox gene famously discovered as the first known regulator of the \u201cSpemann\u201d embryonic organizer.\n                    <jats:italic>Gsc<\/jats:italic>\n                    is expressed in the otic vesicle in a region overlapping with neuroblasts, inducing localized epithelial-to-mesenchymal transition (EMT). Hence, regulation of cellular dynamics appears to be a general function of\n                    <jats:italic>Gsc<\/jats:italic>\n                    during otic neurogenesis as well as in the embryonic organizer.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1609146113","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T23:45:25Z","timestamp":1476920725000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":19,"title":["Spemann organizer gene\n                    <i>Goosecoid<\/i>\n                    promotes delamination of neuroblasts from the otic vesicle"],"prefix":"10.1073","volume":"113","author":[{"given":"Husniye","family":"Kantarci","sequence":"first","affiliation":[{"name":"Biology Department, Texas A&amp;M University, College Station, TX 77843-3258"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gerberding","sequence":"additional","affiliation":[{"name":"Biology Department, Texas A&amp;M University, College Station, TX 77843-3258"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce B.","family":"Riley","sequence":"additional","affiliation":[{"name":"Biology Department, Texas A&amp;M University, College Station, TX 77843-3258"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,10,19]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2002.0820"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80988-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003068"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960129)365:1<113::AID-CNE9>3.0.CO;2-6"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01744256"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902150402"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.3.417"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-010-0984-6"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001630407"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90027-2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.7.3335"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005037"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.009118"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(03)00245-8"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.12.036"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01346"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.07.007"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01587"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1677215"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90632-M"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90288-A"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90069-3"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.117.2.769"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.9.2917"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.9.3005"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.10.027"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608636103"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109695"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg216"},{"key":"e_1_3_3_30_2","first-page":"10784","article-title":"GM130 regulates epithelial-to-mesenchymal transition and invasion of gastric cancer cells via snail","volume":"8","author":"Zhao J","year":"2015","unstructured":"J Zhao, C Yang, S Guo, Y Wu, GM130 regulates epithelial-to-mesenchymal transition and invasion of gastric cancer cells via snail. 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