{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:44:43Z","timestamp":1793083483385,"version":"4.5.0"},"reference-count":46,"publisher":"National Academy of Sciences","issue":"44","license":[{"start":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T00:00:00Z","timestamp":1492387200000},"content-version":"vor","delay-in-days":182,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/501100000272","name":"DH | National Institute for Health Research","doi-asserted-by":"publisher","award":["R01 HL129433"],"award-info":[{"award-number":["R01 HL129433"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"DH | National Institute for Health Research","doi-asserted-by":"publisher","award":["R01 HL118440"],"award-info":[{"award-number":["R01 HL118440"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"DH | National Institute for Health Research","doi-asserted-by":"publisher","award":["R01HL125703"],"award-info":[{"award-number":["R01HL125703"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"DH | National Institute for Health Research","doi-asserted-by":"publisher","award":["R01 CA155432"],"award-info":[{"award-number":["R01 CA155432"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EB009638"],"award-info":[{"award-number":["R01 EB009638"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"DH | National Institute for Health Research","doi-asserted-by":"publisher","award":["K25 EB016673"],"award-info":[{"award-number":["K25 EB016673"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748-50"],"award-info":[{"award-number":["P30 CA008748-50"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>The immune system plays an essential role in the pathophysiology of major diseases such as atherosclerosis, diabetes, and cancer, which has inspired the development of numerous small molecules to modulate immune cells, intending to create immunotherapies for these diseases. Tissue- and cell-specific delivery of these small molecules is the key to transform these compounds to safe, potent immunotherapies. In this study, we present an in vivo nanoparticle screen approach that involves designing and evaluating a library of nanoparticles with distinct immune cell targeting specificity. This study carries out a systematic in vivo immune cell screening to create effective nanoparticle-based immunotherapy for modulating the pathological immune cells in atherosclerosis.<\/jats:p>","DOI":"10.1073\/pnas.1609629113","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T16:37:54Z","timestamp":1476808674000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":111,"title":["Immune cell screening of a nanoparticle library improves atherosclerosis therapy"],"prefix":"10.1073","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8285-5111","authenticated-orcid":false,"given":"Jun","family":"Tang","sequence":"first","affiliation":[{"name":"Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029;"},{"name":"Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Baxter","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Menon","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, 550 First Avenue, New York, NY 10016;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Alaarg","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029;"},{"name":"Department of Biomaterials Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, 7500 AE Enschede, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda L.","family":"Sanchez-Gaytan","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Fay","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Ouimet","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, 550 First Avenue, New York, NY 10016;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounia S.","family":"Braza","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie A.","family":"Longo","sequence":"additional","affiliation":[{"name":"Small-Animal Imaging Core Facility, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalya","family":"Abdel-Atti","sequence":"additional","affiliation":[{"name":"Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Duivenvoorden","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Calcagno","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Storm","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, 7500 AE Enschede, The Netherlands;"},{"name":"Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotirios","family":"Tsimikas","sequence":"additional","affiliation":[{"name":"Sulpizio Cardiovascular Center, Department of Medicine, University of California, San Diego, 9434 Medical Center Drive, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn J.","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, 550 First Avenue, New York, NY 10016;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip K.","family":"Swirski","sequence":"additional","affiliation":[{"name":"Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Nahrendorf","sequence":"additional","affiliation":[{"name":"Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, 550 First Avenue, New York, NY 10016;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"P\u00e9rez-Medina","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahi A.","family":"Fayad","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Reiner","sequence":"additional","affiliation":[{"name":"Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem J. M.","family":"Mulder","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029;"},{"name":"Department of Medical Biochemistry, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,10,17]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3245"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2787"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3520"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230719"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01323"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3589"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3258"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132620"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11260"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M500116-JLR200"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.107.037358"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1400223"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4065"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc500517k"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.2217\/clp.09.38"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.15.6457"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.11.010"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1632"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.03.001"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3793"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2013.12.001"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0103-123"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.678474"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052205"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3780"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4280"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.112059299"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.560177"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2012.08.004"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1411543"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2015.12.026"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000244014.19589.8e"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2172"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11221"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4730"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500858"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501031"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00190.x"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4309"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc400166j"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa1065"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700670104"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3258"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2275"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04157.x"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.158956"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1609629113","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1609629113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T01:30:37Z","timestamp":1649813437000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1609629113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,17]]},"references-count":46,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1073\/pnas.1609629113"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1609629113","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,17]]},"assertion":[{"value":"2016-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}