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Since the protein that forms amyloids in PD, \u03b1-synuclein (aS), is also expressed in the pancreas, we investigated whether it could affect aggregation of the peptide involved in T2D, and vice versa. Using in vitro methods and purified proteins, we here demonstrate that the two proteins cross-react and, importantly, the T2D amyloid protein (both as monomer and amyloid seed) can accelerate aS aggregation. 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