{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:48:27Z","timestamp":1790754507661,"version":"4.1.0"},"reference-count":36,"publisher":"National Academy of Sciences","issue":"36","license":[{"start":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T00:00:00Z","timestamp":1471564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.pnas.org\/preview_site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/501100000925","name":"Department of Health, Australian Government | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1071916"],"award-info":[{"award-number":["1071916"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"Department of Health, Australian Government | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1071916"],"award-info":[{"award-number":["1071916"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"Department of Health, Australian Government | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1102792"],"award-info":[{"award-number":["1102792"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"Department of Health, Australian Government | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1027369"],"award-info":[{"award-number":["1027369"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,9,6]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes with potent antibacterial reactivity. In this study, we investigated whether MAIT cells also contribute to immunity against influenza A viruses. Compared with those who succumbed, hospitalized patients who recovered from severe avian H7N9 influenza infection had higher numbers of MAIT cells. Subsequent in vitro analysis established that MAIT cells from healthy donors are indirectly activated by influenza infection via an IL-18\u2013dependent (but not IL-12\u2013dependent) mechanism requiring the involvement of CD14\n                    <jats:sup>+<\/jats:sup>\n                    monocytes. Our findings highlight the potential for MAIT cells to promote protective immunity in human influenza.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1610750113","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T23:09:31Z","timestamp":1471648171000},"page":"10133-10138","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":262,"title":["Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18\u2013dependent activation"],"prefix":"10.1073","volume":"113","author":[{"given":"Liyen","family":"Loh","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongfang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sneha","family":"Sant","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios","family":"Koutsakos","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinthujan","family":"Jegaskanda","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia;"},{"name":"National Institute of Allergy and Infectious Diseases, Bethesda, MD 20852;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1618-4337","authenticated-orcid":false,"given":"Alexandra J.","family":"Corbett","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligong","family":"Liu","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Disease Research and ARC Centre of Excellence in Advanced Molecular Imaging, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Fairlie","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Disease Research and ARC Centre of Excellence in Advanced Molecular Imaging, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Crowe","sequence":"additional","affiliation":[{"name":"Deepdene Surgery, Deepdene, VIC 3103, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Rossjohn","sequence":"additional","affiliation":[{"name":"Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia;"},{"name":"Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom;"},{"name":"Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Shanghai Public Health Clinical Center and Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education\/Health, Shanghai Medical College of Fudan University, Shanghai 201508, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Doherty","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia;"},{"name":"Department of Immunology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8597-815X","authenticated-orcid":false,"given":"James","family":"McCluskey","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Kedzierska","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,8,19]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130958"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01433"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000054"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000407"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13160"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11605"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1890"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-303339"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4143"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-445429"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-436436"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2014.91"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.09.045"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343509"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7833"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753425913508992"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3142"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20140484"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203218"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1321748111"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1322229111"},{"key":"e_1_3_3_22_2","first-page":"1","article-title":"Prevention and control of influenza with vaccines: Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010","volume":"59","author":"Fiore AE","year":"2010","unstructured":"AE Fiore, , Prevention and control of influenza with vaccines: Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010. MMWR Recomm Rep; Centers for Disease Control and Prevention (CDC) 59, 1\u201362 (2010).","journal-title":"MMWR Recomm Rep"},{"key":"e_1_3_3_23_2","first-page":"285","article-title":"Universal immunity to influenza must outwit immune evasion","volume":"5","author":"Qui\u00f1ones-Parra S","year":"2014","unstructured":"S Qui\u00f1ones-Parra, L Loh, LE Brown, K Kedzierska, SA Valkenburg, Universal immunity to influenza must outwit immune evasion. Front Microbiol 5, 285 (2014).","journal-title":"Front Microbiol"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00060"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201445313"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004210"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636766"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep10942"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200168"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-379479"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.3.1463"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.81"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005072"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.2807\/ese.14.42.19369-en"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2012.01.003"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11653"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1610750113","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1610750113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T01:25:21Z","timestamp":1649813121000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1610750113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,19]]},"references-count":36,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2016,9,6]]}},"alternative-id":["10.1073\/pnas.1610750113"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1610750113","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,19]]},"assertion":[{"value":"2016-08-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}