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Tested on a\n                    <jats:italic>Drosophila<\/jats:italic>\n                    model of the fragile X syndrome, where the number of synapses is in excess, FD44 proves effective to reduce synapse number to normal levels and restore normal learning performance. Our structure\u2013function study shows the specificity of this compound and the drugability of the NCS-1\/Ric8a interface for the treatment of fragile X and possibly, other synaptopathies.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1611089114","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T20:50:39Z","timestamp":1485291039000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":39,"title":["Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome"],"prefix":"10.1073","volume":"114","author":[{"given":"Alicia","family":"Mansilla","sequence":"first","affiliation":[{"name":"Departamento de Neurobiolog\u00eda del Desarrollo, Instituto Cajal, Spanish National Research Council, 28002 Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Chaves-Sanjuan","sequence":"additional","affiliation":[{"name":"Departamento de Cristalograf\u00eda y Biolog\u00eda Estructural, Instituto de Qu\u00edmica F\u00edsica Rocasolano, Spanish National Research Council, 28006 Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria E.","family":"Campillo","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biol\u00f3gicas, Spanish National Research Council, 28040 Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ourania","family":"Semelidou","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Biomedical Sciences Research Centre Alexander Fleming, 16672 Vari, Greece;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loreto","family":"Mart\u00ednez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biol\u00f3gicas, Spanish National Research Council, 28040 Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Infantes","sequence":"additional","affiliation":[{"name":"Departamento de Cristalograf\u00eda y Biolog\u00eda Estructural, Instituto de Qu\u00edmica F\u00edsica Rocasolano, Spanish National Research Council, 28006 Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juana Mar\u00eda","family":"Gonz\u00e1lez-Rubio","sequence":"additional","affiliation":[{"name":"Departamento de Cristalograf\u00eda y Biolog\u00eda Estructural, Instituto de Qu\u00edmica F\u00edsica Rocasolano, Spanish National Research Council, 28006 Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Gil","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biol\u00f3gicas, Spanish National Research Council, 28040 Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Conde","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica M\u00e9dica, Spanish National Research Council, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efthimios M. 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