{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:52:00Z","timestamp":1790707920097,"version":"4.1.0"},"reference-count":26,"publisher":"National Academy of Sciences","issue":"50","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"vor","delay-in-days":197,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,12,13]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Alcohol is a widely consumed drug in western societies that can lead to addiction. A small shift in consumption can have dramatic consequences on public health. We performed the largest genome-wide association metaanalysis and replication study to date (&gt;105,000 individuals) and identified a genetic basis for alcohol consumption during nonaddictive drinking. We found that a locus in the gene encoding \u03b2-Klotho is associated with alcohol consumption. \u03b2-Klotho is an essential receptor component for the endocrine FGFs, FGF19 and FGF21. Using mouse models and pharmacologic administration of FGF21, we show that \u03b2-Klotho in the brain controls alcohol drinking. These findings reveal a mechanism regulating alcohol consumption in humans that may be pharmacologically tractable for reducing alcohol intake.<\/jats:p>","DOI":"10.1073\/pnas.1611243113","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T21:51:19Z","timestamp":1480369879000},"page":"14372-14377","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":246,"title":["<i>KLB<\/i>\n                    is associated with alcohol drinking, and its gene product \u03b2-Klotho is necessary for FGF21 regulation of alcohol preference"],"prefix":"10.1073","volume":"113","author":[{"given":"Gunter","family":"Schumann","sequence":"first","affiliation":[{"name":"Medical Research Council\u2014Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology &amp; Neuroscience, King\u2019s College London, London SE5 8AF, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Liu","sequence":"additional","affiliation":[{"name":"The Framingham Heart Study, Framingham, MA 01702;"},{"name":"The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD 20824;"},{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"O\u2019Reilly","sequence":"additional","affiliation":[{"name":"Medical Research Council\u2014Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology &amp; Neuroscience, King\u2019s College London, London SE5 8AF, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom;"},{"name":"Medical Research Council-Public Health England Centre for Environment and Health, Imperial College London, London W2 1PG, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parkyong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390;"},{"name":"Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xu","sequence":"additional","affiliation":[{"name":"Medical Research Council\u2014Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology &amp; Neuroscience, King\u2019s College London, London SE5 8AF, United 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