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These data indicate that combining immunotoxins like RG7787 that kill cells by inhibiting protein synthesis with actinomycin D is a useful strategy to enhance their antitumor activity in humans.<\/jats:p>","DOI":"10.1073\/pnas.1611481113","type":"journal-article","created":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T21:55:26Z","timestamp":1473198926000},"page":"10666-10671","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":78,"title":["Actinomycin D enhances killing of cancer cells by immunotoxin RG7787 through activation of the extrinsic pathway of apoptosis"],"prefix":"10.1073","volume":"113","author":[{"given":"Xiu Fen","family":"Liu","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laiman","family":"Xiang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Carralot","sequence":"additional","affiliation":[{"name":"Office of Innovation, Hoffman-La Roche AG, 4070 Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Prunotto","sequence":"additional","affiliation":[{"name":"Office of Innovation, Hoffman-La Roche AG, 4070 Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Niederfellner","sequence":"additional","affiliation":[{"name":"Roche Pharmaceutical Research &amp; 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