{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:07:38Z","timestamp":1792591658098,"version":"4.5.0"},"reference-count":49,"publisher":"National Academy of Sciences","issue":"13","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,3,28]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Post-traumatic sterile inflammation is the first necessary step of wound healing. In addition, sterile inflammation underlies the pathogenesis of a multitude of common diseases, such as allergies and autoimmune diseases. The molecular mechanisms underlying sterile inflammation are still not fully understood. Here, we show that the receptor Mincle (Clec4e), the expression of which is highly induced in the skin in response to damage, recognizes cholesterol sulfate, a molecule that is abundant in the epidermal layer of the skin, subsequently inducing a pro-inflammatory response. We also identify a role for Mincle as a driving component in the pathogenesis of allergic skin inflammation. The results demonstrate a previously unconsidered important role of Mincle in mediating sterile inflammation.<\/jats:p>","DOI":"10.1073\/pnas.1611665114","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T20:30:35Z","timestamp":1489523435000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":86,"title":["Receptor Mincle promotes skin allergies and is capable of recognizing cholesterol sulfate"],"prefix":"10.1073","volume":"114","author":[{"given":"Alexey V.","family":"Kostarnoy","sequence":"first","affiliation":[{"name":"Laboratory of Immunobiotechnology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, 123098 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petya G.","family":"Gancheva","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiotechnology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, 123098 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Lepenies","sequence":"additional","affiliation":[{"name":"Immunology Unit, Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, 30559 Hannover, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir I.","family":"Tukhvatulin","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Microbiology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, 123098 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina S.","family":"Dzharullaeva","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Microbiology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, 123098 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita B.","family":"Polyakov","sequence":"additional","affiliation":[{"name":"Laboratory of Detection and Ultrastructural Analysis of Microorganisms, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, 123098 Moscow, Russia;"},{"name":"Laboratory of Instrumental Methods and Organic Reagents, Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, 119991 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniil A.","family":"Grumov","sequence":"additional","affiliation":[{"name":"Laboratory of Detection and Ultrastructural Analysis of Microorganisms, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, 123098 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria A.","family":"Egorova","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiotechnology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, 123098 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey Y.","family":"Kulibin","sequence":"additional","affiliation":[{"name":"Laboratory of Evolutionary Developmental Biology, Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119071 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim A.","family":"Bobrov","sequence":"additional","affiliation":[{"name":"Department of Pathology, M. F. Vladimirsky Moscow Regional Clinical Research Institute, 129110 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina A.","family":"Malolina","sequence":"additional","affiliation":[{"name":"Laboratory of Evolutionary Developmental Biology, Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119071 Moscow, Russia;"},{"name":"Laboratory of Cell Engineering, Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, 123098 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1624-6163","authenticated-orcid":false,"given":"Pavel A.","family":"Zykin","sequence":"additional","affiliation":[{"name":"Department of Cytology and Histology, St. Petersburg State University, 199034 St. Petersburg, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey I.","family":"Soloviev","sequence":"additional","affiliation":[{"name":"Laboratory of Detection and Ultrastructural Analysis of Microorganisms, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, 123098 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0656-7625","authenticated-orcid":false,"given":"Evgeniy","family":"Riabenko","sequence":"additional","affiliation":[{"name":"Department of Control and Applied Mathematics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Russia;"},{"name":"Faculty of Computer Science, Big Data and Information Retrieval School, National Research University Higher School of Economics, Moscow 101000, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana V.","family":"Maltseva","sequence":"additional","affiliation":[{"name":"Scientific Research Centre Bioclinicum, 115088 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry A.","family":"Sakharov","sequence":"additional","affiliation":[{"name":"Scientific Research Centre Bioclinicum, 115088 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G.","family":"Tonevitsky","sequence":"additional","affiliation":[{"name":"Department of Translational Oncology, P. Hertsen Moscow Oncology Research Institute, National Center of Medical Radiological Research, Moscow 125284, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyudmila V.","family":"Verkhovskaya","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biotechnology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, 123098 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis Y.","family":"Logunov","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Microbiology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, 123098 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris S.","family":"Naroditsky","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiotechnology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, 123098 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander L.","family":"Gintsburg","sequence":"additional","affiliation":[{"name":"Laboratory of Gene Engineering of Pathogenic Microorganisms, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, 123098 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.0306164","article-title":"DAMPs, PAMPs and alarmins: All we need to know about danger","volume":"81","author":"Bianchi ME","year":"2007","unstructured":"ME Bianchi, DAMPs, PAMPs and alarmins: All we need to know about danger. J Leukoc Biol 81, 1\u20135 (2007).","journal-title":"J Leukoc Biol"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3389\/fimmu.2015.00422","article-title":"DAMPs from cell death to new life","volume":"6","author":"V\u00e9n\u00e9reau E","year":"2015","unstructured":"E V\u00e9n\u00e9reau, C Ceriotti, ME Bianchi, DAMPs from cell death to new life. Front Immunol 6, 422 (2015).","journal-title":"Front Immunol"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nri2873","article-title":"Sterile inflammation: Sensing and reacting to damage","volume":"10","author":"Chen GY","year":"2010","unstructured":"GY Chen, G Nu\u00f1ez, Sterile inflammation: Sensing and reacting to damage. Nat Rev Immunol 10, 826\u2013837 (2010).","journal-title":"Nat Rev Immunol"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/icb.2015.68","article-title":"The danger model: Questioning an unconvincing theory","volume":"94","author":"J\u00f3zefowski S","year":"2016","unstructured":"S J\u00f3zefowski, The danger model: Questioning an unconvincing theory. Immunol Cell Biol 94, 164\u2013168 (2016).","journal-title":"Immunol Cell Biol"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature17039","article-title":"Reparative inflammation takes charge of tissue regeneration","volume":"529","author":"Karin M","year":"2016","unstructured":"M Karin, H Clevers, Reparative inflammation takes charge of tissue regeneration. Nature 529, 307\u2013315 (2016).","journal-title":"Nature"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fimmu.2014.00288","article-title":"MCL and Mincle: C-type lectin receptors that sense damaged self and pathogen-associated molecular patterns","volume":"5","author":"Richardson MB","year":"2014","unstructured":"MB Richardson, SJ Williams, MCL and Mincle: C-type lectin receptors that sense damaged self and pathogen-associated molecular patterns. Front Immunol 5, 288 (2014).","journal-title":"Front Immunol"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/ni.1651","article-title":"Mincle is an ITAM-coupled activating receptor that senses damaged cells","volume":"9","author":"Yamasaki S","year":"2008","unstructured":"S Yamasaki, , Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat Immunol 9, 1179\u20131188 (2008).","journal-title":"Nat Immunol"},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.4049\/jimmunol.1500102","article-title":"Contribution of MINCLE\u2013SYK signaling to activation of primary human APCs by mycobacterial cord factor and the novel adjuvant TDB","volume":"195","author":"Ostrop J","year":"2015","unstructured":"J Ostrop, , Contribution of MINCLE\u2013SYK signaling to activation of primary human APCs by mycobacterial cord factor and the novel adjuvant TDB. J Immunol 195, 2417\u20132428 (2015).","journal-title":"J Immunol"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.4049\/jimmunol.0904013","article-title":"Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate","volume":"184","author":"Schoenen H","year":"2010","unstructured":"H Schoenen, , Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. J Immunol 184, 2756\u20132760 (2010).","journal-title":"J Immunol"},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0022-2275(20)38006-8","article-title":"Human epidermal lipids: Characterization and modulations during differentiation","volume":"24","author":"Lampe MA","year":"1983","unstructured":"MA Lampe, ML Williams, PM Elias, Human epidermal lipids: Characterization and modulations during differentiation. J Lipid Res 24, 131\u2013140 (1983).","journal-title":"J Lipid Res"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/jcp.1041330320","article-title":"Human bronchial epithelial cells synthesize cholesterol sulfate during squamous differentiation in vitro","volume":"133","author":"Rearick JI","year":"1987","unstructured":"JI Rearick, TW Hesterberg, AM Jetten, Human bronchial epithelial cells synthesize cholesterol sulfate during squamous differentiation in vitro. J Cell Physiol 133, 573\u2013578 (1987).","journal-title":"J Cell Physiol"},{"key":"e_1_3_4_12_2","first-page":"5289","article-title":"Cholesterol sulfate accumulation in tumorigenic and nontumorigenic rat esophageal epithelial cells: Evidence for defective differentiation control in tumorigenic cells","volume":"48","author":"Rearick JI","year":"1988","unstructured":"JI Rearick, GD Stoner, MA George, AM Jetten, Cholesterol sulfate accumulation in tumorigenic and nontumorigenic rat esophageal epithelial cells: Evidence for defective differentiation control in tumorigenic cells. Cancer Res 48, 5289\u20135295 (1988).","journal-title":"Cancer Res"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.immuni.2013.03.010","article-title":"C-type lectin MCL is an FcR\u03b3-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor","volume":"38","author":"Miyake Y","year":"2013","unstructured":"Y Miyake, , C-type lectin MCL is an FcR\u03b3-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor. Immunity 38, 1050\u20131062 (2013).","journal-title":"Immunity"},{"key":"e_1_3_4_14_2","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1089\/neu.2014.3436","article-title":"Mincle signaling in the innate immune response after traumatic brain injury","volume":"32","author":"deRiveroVaccari JC","year":"2015","unstructured":"JC deRiveroVaccari, , Mincle signaling in the innate immune response after traumatic brain injury. J Neurotrauma 32, 228\u201336 (2015).","journal-title":"J Neurotrauma"},{"key":"e_1_3_4_15_2","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1161\/STROKEAHA.115.010088","article-title":"Macrophage-inducible C-type lectin\/spleen tyrosine kinase signaling pathway contributes to neuroinflammation after subarachnoid hemorrhage in rats","volume":"46","author":"He Y","year":"2015","unstructured":"Y He, , Macrophage-inducible C-type lectin\/spleen tyrosine kinase signaling pathway contributes to neuroinflammation after subarachnoid hemorrhage in rats. Stroke 46, 2277\u20132286 (2015).","journal-title":"Stroke"},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals","volume":"464","author":"Duewell P","year":"2010","unstructured":"P Duewell, , NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464, 1357\u20131361 (2010).","journal-title":"Nature"},{"key":"e_1_3_4_17_2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nri3793","article-title":"Cholesterol, inflammation and innate immunity","volume":"15","author":"Tall AR","year":"2015","unstructured":"AR Tall, L Yvan-Charvet, Cholesterol, inflammation and innate immunity. Nat Rev Immunol 15, 104\u2013116 (2015).","journal-title":"Nat Rev Immunol"},{"key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1600-0625.2011.01395.x","article-title":"Extended DNFB-induced contact hypersensitivity models display characteristics of chronic inflammatory dermatoses","volume":"21","author":"R\u00f6se L","year":"2012","unstructured":"L R\u00f6se, C Schneider, C Stock, TM Zollner, WD D\u00f6cke, Extended DNFB-induced contact hypersensitivity models display characteristics of chronic inflammatory dermatoses. Exp Dermatol 21, 25\u201331 (2012).","journal-title":"Exp Dermatol"},{"key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.coi.2013.12.004","article-title":"Molecular determinants of sterile inflammation","volume":"26","author":"Kono H","year":"2014","unstructured":"H Kono, A Onda, T Yanagida, Molecular determinants of sterile inflammation. Curr Opin Immunol 26, 147\u2013156 (2014).","journal-title":"Curr Opin Immunol"},{"key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"a006049","DOI":"10.1101\/cshperspect.a006049","article-title":"Signaling in innate immunity and inflammation","volume":"4","author":"Newton K","year":"2012","unstructured":"K Newton, VM Dixit, Signaling in innate immunity and inflammation. Cold Spring Harb Perspect Biol 4, a006049 (2012).","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"e_1_3_4_21_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/SQB.1989.054.01.003","article-title":"Approaching the asymptote? Evolution and revolution in immunology","volume":"54","author":"Janeway CA","year":"1989","unstructured":"Jr CA Janeway, Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol 54, 1\u201313 (1989).","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1034\/j.1600-065X.2000.917309.x","article-title":"Innate immune recognition: Mechanisms and pathways","volume":"173","author":"Medzhitov R","year":"2000","unstructured":"R Medzhitov, Jr C Janeway, Innate immune recognition: Mechanisms and pathways. Immunol Rev 173, 89\u201397 (2000).","journal-title":"Immunol Rev"},{"key":"e_1_3_4_23_2","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1146\/annurev.iy.12.040194.005015","article-title":"Tolerance, danger, and the extended family","volume":"12","author":"Matzinger P","year":"1994","unstructured":"P Matzinger, Tolerance, danger, and the extended family. Annu Rev Immunol 12, 991\u20131045 (1994).","journal-title":"Annu Rev Immunol"},{"key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1126\/science.1071059","article-title":"The danger model: A renewed sense of self","volume":"296","author":"Matzinger P","year":"2002","unstructured":"P Matzinger, The danger model: A renewed sense of self. Science 296, 301\u2013305 (2002).","journal-title":"Science"},{"key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nature11047","article-title":"Allergic host defences","volume":"484","author":"Palm NW","year":"2012","unstructured":"NW Palm, RK Rosenstein, R Medzhitov, Allergic host defences. Nature 484, 465\u2013472 (2012).","journal-title":"Nature"},{"key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"25322","DOI":"10.1074\/jbc.M115.645234","article-title":"Human Mincle binds to cholesterol crystals and triggers innate immune responses","volume":"290","author":"Kiyotake R","year":"2015","unstructured":"R Kiyotake, , Human Mincle binds to cholesterol crystals and triggers innate immune responses. J Biol Chem 290, 25322\u201325332 (2015).","journal-title":"J Biol Chem"},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"30052","DOI":"10.1074\/jbc.M114.588574","article-title":"C-type lectin receptor dectin-3 mediates trehalose 6,6\u2032-dimycolate (TDM)-induced Mincle expression through CARD9\/Bcl10\/MALT1-dependent nuclear factor (NF)-\u03baB activation","volume":"289","author":"Zhao XQ","year":"2014","unstructured":"XQ Zhao, , C-type lectin receptor dectin-3 mediates trehalose 6,6\u2032-dimycolate (TDM)-induced Mincle expression through CARD9\/Bcl10\/MALT1-dependent nuclear factor (NF)-\u03baB activation. J Biol Chem 289, 30052\u201330062 (2014).","journal-title":"J Biol Chem"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1038\/ncomms5982","article-title":"Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis","volume":"5","author":"Tanaka M","year":"2014","unstructured":"M Tanaka, , Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis. Nat Commun 5, 4982 (2014).","journal-title":"Nat Commun"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.4049\/jimmunol.1502355","article-title":"Mincle activation and the Syk\/Card9 signaling axis are central to the development of autoimmune disease of the eye","volume":"196","author":"Lee EJ","year":"2016","unstructured":"EJ Lee, , Mincle activation and the Syk\/Card9 signaling axis are central to the development of autoimmune disease of the eye. J Immunol 196, 3148\u20133158 (2016).","journal-title":"J Immunol"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nature17403","article-title":"The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression","volume":"532","author":"Seifert L","year":"2016","unstructured":"L Seifert, , The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. Nature 532, 245\u2013249 (2016).","journal-title":"Nature"},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/j.1398-9995.2011.02652.x","article-title":"Mechanisms of chemical-induced innate immunity in allergic contact dermatitis","volume":"66","author":"Martin SF","year":"2011","unstructured":"SF Martin, , Mechanisms of chemical-induced innate immunity in allergic contact dermatitis. Allergy 66, 1152\u20131163 (2011).","journal-title":"Allergy"},{"key":"e_1_3_4_32_2","doi-asserted-by":"crossref","first-page":"5826","DOI":"10.4049\/jimmunol.180.9.5826","article-title":"Danger signaling through the inflammasome acts as a master switch between tolerance and sensitization","volume":"180","author":"Watanabe H","year":"2008","unstructured":"H Watanabe, , Danger signaling through the inflammasome acts as a master switch between tolerance and sensitization. J Immunol 180, 5826\u20135832 (2008).","journal-title":"J Immunol"},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1172\/JCI118899","article-title":"Dissection of antigenic and irritative effects of epicutaneously applied haptens in mice. Evidence that not the antigenic component but nonspecific proinflammatory effects of haptens determine the concentration-dependent elicitation of allergic contact dermatitis","volume":"98","author":"Grabbe S","year":"1996","unstructured":"S Grabbe, , Dissection of antigenic and irritative effects of epicutaneously applied haptens in mice. Evidence that not the antigenic component but nonspecific proinflammatory effects of haptens determine the concentration-dependent elicitation of allergic contact dermatitis. J Clin Invest 98, 1158\u20131164 (1996).","journal-title":"J Clin Invest"},{"key":"e_1_3_4_34_2","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1038\/sj.jid.5700726","article-title":"Skin contact irritation conditions the development and severity of allergic contact dermatitis","volume":"127","author":"Bonneville M","year":"2007","unstructured":"M Bonneville, , Skin contact irritation conditions the development and severity of allergic contact dermatitis. J Invest Dermatol 127, 1430\u20131435 (2007).","journal-title":"J Invest Dermatol"},{"key":"e_1_3_4_35_2","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1084\/jem.20101102","article-title":"Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons","volume":"207","author":"Gregorio J","year":"2010","unstructured":"J Gregorio, , Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons. J Exp Med 207, 2921\u20132930 (2010).","journal-title":"J Exp Med"},{"key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1038\/ncomms4755","article-title":"An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells","volume":"5","author":"Yasukawa S","year":"2014","unstructured":"S Yasukawa, , An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells. Nat Commun 5, 3755 (2014).","journal-title":"Nat Commun"},{"key":"e_1_3_4_37_2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nri.2016.55","article-title":"C-type lectin receptors in the control of T helper cell differentiation","volume":"16","author":"Geijtenbeek TB","year":"2016","unstructured":"TB Geijtenbeek, SI Gringhuis, C-type lectin receptors in the control of T helper cell differentiation. Nat Rev Immunol 16, 433\u2013448 (2016).","journal-title":"Nat Rev Immunol"},{"key":"e_1_3_4_38_2","doi-asserted-by":"crossref","first-page":"14292","DOI":"10.1073\/pnas.1009234107","article-title":"Proinflammatory T helper type 17 cells are effective B-cell helpers","volume":"107","author":"Mitsdoerffer M","year":"2010","unstructured":"M Mitsdoerffer, , Proinflammatory T helper type 17 cells are effective B-cell helpers. Proc Natl Acad Sci USA 107, 14292\u201314297 (2010).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"261037","DOI":"10.1155\/2013\/261037","article-title":"Role of Th17 cells in skin inflammation of allergic contact dermatitis","volume":"2013","author":"Peiser M","year":"2013","unstructured":"M Peiser, Role of Th17 cells in skin inflammation of allergic contact dermatitis. Clin Dev Immunol 2013, 261037 (2013).","journal-title":"Clin Dev Immunol"},{"key":"e_1_3_4_40_2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s12016-016-8535-x","article-title":"The inflammatory response in psoriasis: A comprehensive review","volume":"50","author":"Deng Y","year":"2016","unstructured":"Y Deng, C Chang, Q Lu, The inflammatory response in psoriasis: A comprehensive review. Clin Rev Allergy Immunol 50, 377\u2013389 (2016).","journal-title":"Clin Rev Allergy Immunol"},{"key":"e_1_3_4_41_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ajpath.2012.03.044","article-title":"Th17 cells: Biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies","volume":"181","author":"Maddur MS","year":"2012","unstructured":"MS Maddur, P Miossec, SV Kaveri, J Bayry, Th17 cells: Biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies. Am J Pathol 181, 8\u201318 (2012).","journal-title":"Am J Pathol"},{"key":"e_1_3_4_42_2","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1194\/jlr.R300005-JLR200","article-title":"Cholesterol sulfate in human physiology: What\u2019s it all about?","volume":"44","author":"Strott CA","year":"2003","unstructured":"CA Strott, Y Higashi, Cholesterol sulfate in human physiology: What\u2019s it all about? J Lipid Res 44, 1268\u20131278 (2003).","journal-title":"J Lipid Res"},{"key":"e_1_3_4_43_2","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s00421-011-2048-3","article-title":"Passing the anaerobic threshold is associated with substantial changes in the gene expression profile in white blood cells","volume":"112","author":"Sakharov DA","year":"2012","unstructured":"DA Sakharov, , Passing the anaerobic threshold is associated with substantial changes in the gene expression profile in white blood cells. Eur J Appl Physiol 112, 963\u2013972 (2012).","journal-title":"Eur J Appl Physiol"},{"key":"e_1_3_4_44_2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/bjc.2013.774","article-title":"c-FOS suppresses ovarian cancer progression by changing adhesion","volume":"110","author":"Oliveira-Ferrer L","year":"2014","unstructured":"L Oliveira-Ferrer, , c-FOS suppresses ovarian cancer progression by changing adhesion. Br J Cancer 110, 753\u2013763 (2014).","journal-title":"Br J Cancer"},{"key":"e_1_3_4_45_2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/abio.1997.2143","article-title":"Successive isolation and separation of the major lipid fractions including gangliosides from single biological samples","volume":"249","author":"Dreyfus H","year":"1997","unstructured":"H Dreyfus, B Gu\u00e9rold, L Freysz, D Hicks, Successive isolation and separation of the major lipid fractions including gangliosides from single biological samples. Anal Biochem 249, 67\u201378 (1997).","journal-title":"Anal Biochem"},{"key":"e_1_3_4_46_2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1471-4159.1980.tb12515.x","article-title":"The use of Sep-Pak C18 cartridges during the isolation of gangliosides","volume":"35","author":"Williams MA","year":"1980","unstructured":"MA Williams, RH McCluer, The use of Sep-Pak C18 cartridges during the isolation of gangliosides. J Neurochem 35, 266\u2013269 (1980).","journal-title":"J Neurochem"},{"key":"e_1_3_4_47_2","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1194\/jlr.D800038-JLR200","article-title":"Targeted analysis of ganglioside and sulfatide molecular species by LC\/ESI-MS\/MS with theoretically expanded multiple reaction monitoring","volume":"49","author":"Ikeda K","year":"2008","unstructured":"K Ikeda, T Shimizu, R Taguchi, Targeted analysis of ganglioside and sulfatide molecular species by LC\/ESI-MS\/MS with theoretically expanded multiple reaction monitoring. J Lipid Res 49, 2678\u20132689 (2008).","journal-title":"J Lipid Res"},{"key":"e_1_3_4_48_2","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1084\/jem.176.6.1693","article-title":"Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte\/macrophage colony-stimulating factor","volume":"176","author":"Inaba K","year":"1992","unstructured":"K Inaba, , Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte\/macrophage colony-stimulating factor. J Exp Med 176, 1693\u20131702 (1992).","journal-title":"J Exp Med"},{"key":"e_1_3_4_49_2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.talanta.2013.04.075","article-title":"Determination of plasma cholesterol sulfate by LC-APCI-MS\/MS in the context of pediatric autism","volume":"116","author":"Fong BMW","year":"2013","unstructured":"BMW Fong, S Tam, KSY Leung, Determination of plasma cholesterol sulfate by LC-APCI-MS\/MS in the context of pediatric autism. Talanta 116, 115\u2013121 (2013).","journal-title":"Talanta"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1611665114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T11:35:59Z","timestamp":1654601759000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1611665114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,14]]},"references-count":49,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2017,3,28]]}},"alternative-id":["10.1073\/pnas.1611665114"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1611665114","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,14]]},"assertion":[{"value":"2017-03-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}