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The accumulation of conditionally unstable proteins would overload cellular protein degradation systems; consequently, these proteins would contribute to amyloidogenesis and protein aggregation disorders. Because nutritional deficits often develop in aging organisms, this study provides an additional, protein stability-based explanation of the connection between vitamin supplies and healthy aging.<\/jats:p>","DOI":"10.1073\/pnas.1611994113","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T22:50:26Z","timestamp":1476312626000},"page":"12156-12161","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":70,"title":["Recognition of enzymes lacking bound cofactor by protein quality control"],"prefix":"10.1073","volume":"113","author":[{"given":"Adri\u00e1n","family":"Mart\u00ednez-Lim\u00f3n","sequence":"first","affiliation":[{"name":"Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, D-60438 Frankfurt am Main, Germany;"},{"name":"Institute of Biophysical Chemistry, Goethe University Frankfurt, D-60438 Frankfurt am Main, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Alriquet","sequence":"additional","affiliation":[{"name":"Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, D-60438 Frankfurt am Main, Germany;"},{"name":"Institute of Biophysical Chemistry, Goethe University Frankfurt, D-60438 Frankfurt am Main, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Han","family":"Lang","sequence":"additional","affiliation":[{"name":"Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, D-60438 Frankfurt am Main, Germany;"},{"name":"Institute of Biophysical Chemistry, Goethe University Frankfurt, D-60438 Frankfurt am Main, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Calloni","sequence":"additional","affiliation":[{"name":"Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, D-60438 Frankfurt am Main, Germany;"},{"name":"Institute of Biophysical Chemistry, Goethe University Frankfurt, D-60438 Frankfurt am Main, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilka","family":"Wittig","sequence":"additional","affiliation":[{"name":"Functional Proteomics, Sonderforschungsbereich 815 Core Unit, School of Medicine, Goethe University Frankfurt, D-60590 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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