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We found that equine infectious anemia virus, which causes a debilitating disease in horses, also has acquired the capacity to protect the virus particle from inhibition by SERINC5 and SERINC3 by using its small protein S2. That three different retroviruses have independently evolved the ability to elude inhibition by SERINC5 and SERINC3 indicates that these cellular factors play a fundamental role against various retrovirus pathogens.<\/jats:p>","DOI":"10.1073\/pnas.1612044113","type":"journal-article","created":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T22:44:11Z","timestamp":1478040251000},"page":"13197-13202","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":96,"title":["S2 from equine infectious anemia virus is an infectivity factor which counteracts the retroviral inhibitors SERINC5 and SERINC3"],"prefix":"10.1073","volume":"113","author":[{"given":"Ajit","family":"Chande","sequence":"first","affiliation":[{"name":"Centre for Integrative Biology, University of Trento, 38123 Trento, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia 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