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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,9,13]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Our work shows a remarkable synergy between physiological levels of vitamin C and 5-aza-CdR. The combination enhances the viral mimicry response to DNA methyltransferase inhibitors, including the upregulation of endogenous retroviruses in the dsRNA form and the induction of viral defense pathways. Because patients with hematological and other cancers are often markedly vitamin C deficient, the addition of vitamin C to treatment protocols may be a straightforward way to increase the clinical efficacy of such drugs in patients with myelodysplastic syndrome and leukemia.<\/jats:p>","DOI":"10.1073\/pnas.1612262113","type":"journal-article","created":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T22:33:17Z","timestamp":1472509997000},"page":"10238-10244","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":195,"title":["Vitamin C increases viral mimicry induced by 5-aza-2\u2032-deoxycytidine"],"prefix":"10.1073","volume":"113","author":[{"given":"Minmin","family":"Liu","sequence":"first","affiliation":[{"name":"Van Andel Research Institute, Grand Rapids, MI 49503;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Ohtani","sequence":"additional","affiliation":[{"name":"Van Andel Research Institute, Grand Rapids, MI 49503;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanding","family":"Zhou","sequence":"additional","affiliation":[{"name":"Van Andel Research Institute, Grand Rapids, MI 49503;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas Due","family":"\u00d8rskov","sequence":"additional","affiliation":[{"name":"Department of Hematology, Rigshospitalet, 2100 Copenhagen \u00d8, Denmark;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Charlet","sequence":"additional","affiliation":[{"name":"Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang W.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Shen","sequence":"additional","affiliation":[{"name":"Van Andel Research Institute, Grand Rapids, MI 49503;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Baylin","sequence":"additional","affiliation":[{"name":"Van Andel Research Institute, Grand Rapids, MI 49503;"},{"name":"Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangning","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Gr\u00f8nb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Hematology, Rigshospitalet, 2100 Copenhagen \u00d8, Denmark;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Jones","sequence":"additional","affiliation":[{"name":"Van Andel Research Institute, Grand Rapids, MI 49503;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,8,29]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nrc3130","article-title":"A decade of exploring the cancer epigenome - biological and translational implications","volume":"11","author":"Baylin SB","year":"2011","unstructured":"SB Baylin, PA Jones, A decade of exploring the cancer epigenome - biological and translational implications. 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