{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:50:16Z","timestamp":1789599016039,"version":"build-2803163510"},"reference-count":33,"publisher":"National Academy of Sciences","issue":"3","license":[{"start":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T00:00:00Z","timestamp":1499040000000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"crossref","award":["S2010\/BMD-2374"],"award-info":[{"award-number":["S2010\/BMD-2374"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2014-58769-P"],"award-info":[{"award-number":["SAF2014-58769-P"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Ministry of Economy and Competitiveness | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/00398"],"award-info":[{"award-number":["PI16\/00398"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Ministry of Economy and Competitiveness | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CB16\/11\/00303"],"award-info":[{"award-number":["CB16\/11\/00303"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Ministry of Economy and Competitiveness | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CB16\/11\/00504"],"award-info":[{"award-number":["CB16\/11\/00504"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Ministry of Economy and Competitiveness | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["AC14\/00029"],"award-info":[{"award-number":["AC14\/00029"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008061","name":"Fundaci\u00f3n Mutua Madrile\u00f1a","doi-asserted-by":"crossref","award":["AP153622014"],"award-info":[{"award-number":["AP153622014"]}],"id":[{"id":"10.13039\/100008061","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007406","name":"Fundacion BBVA","doi-asserted-by":"publisher","award":["68-2015"],"award-info":[{"award-number":["68-2015"]}],"id":[{"id":"10.13039\/100007406","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01- HL122352"],"award-info":[{"award-number":["R01- HL122352"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","award":["2009"],"award-info":[{"award-number":["2009"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,1,17]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Tbx20 is a transcription factor whose critical role in cardiogenesis is well-established. Here we functionally analyzed the electrophysiological effects produced by a mutation (p.R311C) in Tbx20 found in some affected individuals belonging to a family with long QT syndrome (an inherited cardiac arrhythmia due to delayed ventricular repolarization). We demonstrated that Tbx20 selectively increases the expression of\n                    <jats:italic>KCNH2<\/jats:italic>\n                    , which encodes for the channel Kv11.1 (hERG) that generates the main ventricular repolarizing current. Conversely, the p.R311C mutation disables the Tbx20 protranscriptional activity over\n                    <jats:italic>KCNH2<\/jats:italic>\n                    , leading to a decrease in the hERG current and a prolongation of the action potentials recorded in human induced pluripotent stem cell-derived cardiomyocytes. Therefore, we propose that Tbx20, besides its described role, regulates\n                    <jats:italic>KCNH2<\/jats:italic>\n                    expression.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1612383114","type":"journal-article","created":{"date-parts":[[2017,1,3]],"date-time":"2017-01-03T20:50:20Z","timestamp":1483476620000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":47,"title":["Tbx20 controls the expression of the\n                    <i>KCNH2<\/i>\n                    gene and of hERG channels"],"prefix":"10.1073","volume":"114","author":[{"given":"Ricardo","family":"Caballero","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Universidad Complutense, 28040 Madrid, Spain;"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER), Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel G.","family":"Utrilla","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Universidad Complutense, 28040 Madrid, Spain;"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER), Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Amor\u00f3s","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Universidad Complutense, 28040 Madrid, Spain;"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER), Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Matamoros","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Universidad Complutense, 28040 Madrid, Spain;"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER), Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"P\u00e9rez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Universidad Complutense, 28040 Madrid, Spain;"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER), Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tinaquero","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Universidad Complutense, 28040 Madrid, Spain;"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER), Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Alfayate","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Universidad Complutense, 28040 Madrid, Spain;"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER), Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Nieto-Mar\u00edn","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Universidad Complutense, 28040 Madrid, Spain;"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER), Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Guerrero-Serna","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48109;"},{"name":"Department of Molecular and Integrative Physiology, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-hua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48109;"},{"name":"Department of Molecular and Integrative Physiology, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Ramos-Mondrag\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48109;"},{"name":"Department of Molecular and Integrative Physiology, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Ponce-Balbuena","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48109;"},{"name":"Department of Molecular and Integrative Physiology, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Herron","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48109;"},{"name":"Department of Molecular and Integrative Physiology, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine F.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48109;"},{"name":"Department of Molecular and Integrative Physiology, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Filgueiras-Rama","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario La Paz, Instituto de Investigaci\u00f3n Sanitaria La Paz (IdiPaz), 28046 Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Peinado","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER), Spain;"},{"name":"Department of Cardiology, Hospital Universitario La Paz, Instituto de Investigaci\u00f3n Sanitaria La Paz (IdiPaz), 28046 Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"L\u00f3pez-Send\u00f3n","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER), Spain;"},{"name":"Department of Cardiology, Hospital Universitario La Paz, Instituto de Investigaci\u00f3n Sanitaria La Paz (IdiPaz), 28046 Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0080-3500","authenticated-orcid":false,"given":"Jos\u00e9","family":"Jalife","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48109;"},{"name":"Department of Molecular and Integrative Physiology, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48109;"},{"name":"Cardiac Arrhythmia Department, Fundaci\u00f3n Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Delp\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Universidad Complutense, 28040 Madrid, Spain;"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER), Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Tamargo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Universidad Complutense, 28040 Madrid, Spain;"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER), Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,1,3]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2015.74"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.020"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00243-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds034"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808705105"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59472"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.863076"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00891.2003"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.107.5.611"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.12.026"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.11.032"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-1-00285.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.003638"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1323548111"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.114.001709"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01026.2007"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvw009"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv280"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-020911-153336"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.07.019"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000335760.02995.ca"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2004.01.006"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1086\/519530"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/384080a0"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.112.6.651"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp047"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02099"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.4.529"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2015.06.009"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1004021107"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.215269"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs313"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02850-4"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1612383114","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1612383114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T01:50:35Z","timestamp":1649814635000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1612383114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,1,17]]}},"alternative-id":["10.1073\/pnas.1612383114"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1612383114","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,3]]},"assertion":[{"value":"2017-01-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}