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The same effect is seen with\n equimolar doses of AR-M1896 or AR-M961, an agonist both at GalR1 and\n GalR2 receptors. In allodynic Bennett model rats, the mechanical\n threshold increased dose-dependently after intrathecal injection of a\n high dose of AR-M961, whereas no effect was observed in the control or\n AR-M1896 group. No effect of either of the two compounds was observed\n in nonallodynic Bennett model rats. These data indicate that a low dose\n of galanin has a nociceptive role at the spinal cord level mediated by\n GalR2 receptors, whereas the antiallodynic effect of high-dose galanin\n on neuropathic pain is mediated by the GalR1 receptors. Thus, a\n selective GalR1 agonist may be used to treat neuropathic pain.<\/jats:p>","DOI":"10.1073\/pnas.161293598","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:34:10Z","timestamp":1027679650000},"page":"9960-9964","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":199,"title":["Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: Selective actions via GalR1 and GalR2 receptors"],"prefix":"10.1073","volume":"98","author":[{"given":"Hong-Xiang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, S-171 77\r Stockholm, Sweden; and AstraZeneca R &amp; D Montreal, Ville\r Satin-Laurient, Montreal, QC, Canada H4S 1Z9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Brumovsky","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, S-171 77\r Stockholm, Sweden; and AstraZeneca R &amp; D Montreal, Ville\r Satin-Laurient, Montreal, QC, Canada H4S 1Z9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, S-171 77\r Stockholm, Sweden; and AstraZeneca R &amp; D Montreal, Ville\r Satin-Laurient, Montreal, QC, Canada H4S 1Z9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, S-171 77\r Stockholm, Sweden; and AstraZeneca R &amp; D Montreal, Ville\r Satin-Laurient, Montreal, QC, Canada H4S 1Z9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemal","family":"Payza","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, S-171 77\r Stockholm, Sweden; and AstraZeneca R &amp; D Montreal, Ville\r Satin-Laurient, Montreal, QC, Canada H4S 1Z9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lejla","family":"Hodzic","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, S-171 77\r Stockholm, Sweden; and AstraZeneca R &amp; D Montreal, Ville\r Satin-Laurient, Montreal, QC, Canada H4S 1Z9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantevy","family":"Pou","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, S-171 77\r Stockholm, Sweden; and AstraZeneca R &amp; D Montreal, Ville\r Satin-Laurient, Montreal, QC, Canada H4S 1Z9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Godbout","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, S-171 77\r Stockholm, Sweden; and AstraZeneca R &amp; D Montreal, Ville\r Satin-Laurient, Montreal, QC, Canada H4S 1Z9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"H\u00f6kfelt","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, S-171 77\r Stockholm, Sweden; and AstraZeneca R &amp; D Montreal, Ville\r Satin-Laurient, Montreal, QC, Canada H4S 1Z9"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2001,7,31]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(83)80033-7"},{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","unstructured":"H\u00f6kfelt T. 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